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DMS11 protein (Arabidopsis thaliana) - STRING interaction network
"DMS11" - DEFECTIVE IN MERISTEM SILENCING 11 in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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DMS11DEFECTIVE IN MERISTEM SILENCING 11; Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing (PubMed-22560611, PubMed-23675613). Exhibits ATPase activity (PubMed-22560611). May also be involved in the regulation of chromatin architecture to maintain gene silencing (PubMed-22555433). Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity. Probably involved in DNA repair (By similarity) (663 aa)    
Predicted Functional Partners:
DMS3
DEFECTIVE IN MERISTEM SILENCING 3; Component of the RNA-directed DNA methylation (RdDM) machinery, probably by facilitating an RNAi-mediated epigenetic modification involving secondary siRNAs and spreading of DNA methylation, thus leading to gene silencing. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex. Required for de novo DNA methylation (420 aa)
     
 
  0.982
RDM1
RNA-DIRECTED DNA METHYLATION 1; Regulator of RNA-directed DNA methylation (RdDM). Binds to single-stranded methyl DNA. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex (163 aa)
     
   
  0.813
IDN2
INVOLVED IN DE NOVO 2; Forms a complex with FDM1/IDNL1 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway (PubMed-22570638, PubMed-22592791) and downstream of small interfering RNA (siRNA) formation (PubMed-22810086). Required for de novo DNA methylation, siRNA accumulation and siRNA-mediated maintenance methylation (PubMed-19915591). Required for several post-transcriptional gene silencing pathways (PubMed-20059743). Binds double-stranded RNAs (dsRNAs) with 5’-overhangs through its XS domain (PubMed-19915 [...] (647 aa)
     
   
  0.792
CHB3
SWI/SNF complex subunit SWI3D; Component of a multiprotein complex equivalent of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors (986 aa)
     
   
  0.789
DRD1
DEFECTIVE IN RNA-DIRECTED DNA METHYLATION 1; Subunit of the chromatin-remodeling complex (DDR complex) that mediates RNA polymerases IV and V (Pol IV and Pol V) recruitment to chromatin (PubMed-19013275, PubMed-22864289). Cooperates with Pol IV and Pol V to regulates RNA- and RNAi- (RNA interference) directed non-CpG de novo DNA methylation on cytosine of genes targeted for silencing and enhancers, also known as siRNA-directed DNA methylation (RdDM), thus leading to epigenetic modification of the genome and promoting/maintaining heterochromatin (PubMed-15120073, PubMed-15947783, PubMed [...] (888 aa)
     
   
  0.780
AT3G20010
SNF2 and helicase domain-containing protein; Probable helicase-like transcription factor involved in transcriptional gene silencing. Associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. May be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin (PubMed-25420628). Associates with SUVR2 and functions redundantly with FRG2. Required for the efficient methylation of a broad range of RdDM target loci (PubMed-25425661) (1047 aa)
     
   
  0.753
SUVH9
SU(VAR)3-9 homolog 9; Histone methyltransferase family member that plays a role in gene silencing. According to PubMed-19043555, the protein does not bind S-adenosyl-L-methionine and lacks methyltransferase activity. Instead, it may function downstream of DRM2 in RNA- directed DNA methylation, binding to methylated DNA and recruiting DNA-directed RNA polymerase V to chromatin (PubMed-24463519) (650 aa)
           
  0.714
POL
Poltergeist; Involved in the regulation of pedicel length and of CLAVATA pathways controlling stem cell identity at shoot and flower meristems (856 aa)
     
   
  0.708
NRPD1B
Nuclear RNA polymerase D1B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase V involved in RNA-directed DNA methylation-dependent (RdDM) silencing of endogenous repeated sequences, including transposable elements. Also required for full erasure of methylation when the RNA trigger is withdrawn. Seems also involved in the synthesis of short-interfering RNAs (siRNA). Essential component of a self- reinforcing loop coupling de novo DNA methylation to siRNA pr [...] (1976 aa)
     
   
  0.701
CRT1
Compromised recognition of TCV 1; Mediator of defense signaling triggered by distinct classes of R proteins. Required during hypersensitive response (HR) that confers disease resistance to turnip crinkle virus (TCV). Exhibits ATPase activity (PubMed-18191794, PubMed-19704828). Contributes to resistance against Pseudomonas syringae and Hyaloperonospora arabidopsidis, at early stages prior to cytosolic calcium ions Ca(2+) accumulation (PubMed-20332379). Required for pathogen-associated molecular pattern (PAMP)- triggered immunity (PTI), basal resistance, non-host resistance and systemic [...] (635 aa)
     
 
0.698
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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