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JMJ18 protein (Arabidopsis thaliana) - STRING interaction network
"JMJ18" - Jumonji domain-containing protein 18 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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JMJ18Jumonji domain-containing protein 18; Histone demethylase that demethylates ’Lys-4’ (H3K4me) of histone H3 with a specific activity for H3K4me3 and H3K4me2. No activity on H3K9me3/2, H3K27me3/2 and H3K36me3/2. Involved in the control of flowering time by demethylating H3K4me3 at the FLC locus and repressing its expression. The repression of FLC level and reduction in H3K4me3 at the FLC locus results in induction of the flowering activator FT, which is a downstream target of FLC (819 aa)    
Predicted Functional Partners:
ATX2
Trithorax-like protein 2; Histone methyltransferase (1083 aa)
     
 
  0.777
SDG14
SET domain protein 14; Histone methyltransferase (1018 aa)
     
 
  0.740
SDG29
SET domain group 29; Histone methyltransferase (1043 aa)
     
 
  0.723
SDG16
SET domain protein 16; Histone methyltransferase (1027 aa)
     
 
  0.721
SET27
Homologue of trithorax; Histone methyltransferase. Methylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Required to maintain the active state of class A (AP1 and AP2), class B (PI and AP3) and class C (AG) floral homeotic genes at early stages of flower development. Regulates floral organ identity and flowering transition. Functions as a receptor for the lipid messenger phosphatidylinositol 5-phosphate (PI5P), which regulates negatively its transcriptional activation activity (1062 aa)
     
 
  0.708
TRO
TRAUCO; Trithorax-group gene homolog required for early embryogenesis (PubMed-20118203, PubMed-21423667). Required for the expression of FLC and FLC homologs and represses flowering (PubMed-21423667). Required for proper leaf growth and development (PubMed-21423667). Part of COMPASS-like complexes responsible for H3K4 trimethylation, but not for di- or mono-methylation of histone H3 ’Lys-4’ (PubMed-21423667). Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed-21423667) (509 aa)
       
 
  0.702
HAT3.1
Homeobox protein HAT3.1; Binds only to large DNA fragments. Recognizes a DNA fragment carrying 8 copies of box7 motif of the light-induced cab- E promoter of Nicotiana plumbaginifolia. Also recognizes the box7m1 motif (723 aa)
     
 
  0.678
SDG2
SET domain protein 2; Histone methyltransferase specifically required for trimethylation of ’Lys-4’ of histone H3 (H3K4me3) and is crucial for both sporophyte and gametophyte development (PubMed-21037105, PubMed-20937886) (2335 aa)
     
 
  0.659
AT5G28340
Pentatricopeptide repeat-containing protein (435 aa)
     
 
  0.648
SUVH6
SU(VAR)3-9 homolog 6; Histone methyltransferase. Methylates ’Lys-9’ of histone H3. H3 ’Lys-9’ methylation represents a specific tag for epigenetic transcriptional repression. Seems to act preferentially on dsMRNA (790 aa)
     
 
  0.644
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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