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AGO3 protein (Arabidopsis thaliana) - STRING interaction network
"AGO3" - Protein argonaute 3 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AGO3Protein argonaute 3; Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression (By similarity) (1194 aa)    
Predicted Functional Partners:
AT2G03780
Uncharacterized protein At2g03780/F19B11.23; Translin family protein; Its function is described as sequence-specific DNA binding, DNA binding; Involved in biological_process unknown; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Translin, C-terminal (InterPro-IPR016069), Translin (InterPro-IPR002848), Translin, N-terminal (InterPro-IPR016068); Has 561 Blast hits to 561 proteins in 195 species- Archae - 92; Bacteria - 2; Metazoa - 209; Fungi - 153; Plants - 36; Viruses - 0; Other Eukaryotes - 69 (source- NCBI BLink) (287 aa)
       
  0.945
AT2G37020
Translin family protein; Its function is described as sequence-specific DNA binding, DNA binding; Involved in biological_process unknown; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Translin, C-terminal (InterPro-IPR016069), Translin (InterPro-IPR002848), Translin, N-terminal (InterPro-IPR016068) (310 aa)
       
  0.937
AT5G21030
PAZ domain-containing protein / piwi domain-containing protein; Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression (By similarity) (850 aa)
     
 
0.929
AGO4
Argonaute family protein; Together with RDM3, required for transcriptional gene silencing (TGS) by DNA methylation and repressive histone modifications (H3K9me2) of several chromatin loci. Component of the RISC complex that associate with the small interfering RNA (siRNA) pathway involved in direct cytosine methylation at endogenous DNA repeats. Forms a AGO4/NRPE1/siRNA complex in cajal body, facilitating its function in RNA-directed gene silencing of target loci. Required for CpNpG and asymmetric DNA methylation as well as histone H3 ’Lys-9’ methylation (H3K9me) at SUP and SN1 loci. M [...] (924 aa)
     
 
0.928
AGO9
Argonaute family protein; Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates preferentially with small RNAs of 24 nucleotide in length with a 5’ terminal adenosine. Interacts with 24 nucleotide sRNAs derived from transposable elements (TEs). Required to silence pericentrometric-located [...] (896 aa)
     
 
0.926
AGO6
Argonaute family protein; Involved in transcriptional gene silencing (TGS). Component of the RISC complex that associate with the small interfering RNA (siRNA) pathway involved in direct cytosine methylation at endogenous DNA repeats. Required for the accumulation of specific siRNAs derived from transgene and heterochromatin-related endogenous loci. Involved in RNA-directed DNA methylation (RdDM) at specific endogenous loci. Probably not required for the accumulation of siRNAs derived from transgene inverted repeats that induce post-transcriptional gene silencing (PTGS). Associates mai [...] (878 aa)
         
0.923
AGO5
Argonaute family protein; Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates with siRNAs of various sizes, from 21-24 nucleotide in length and preferentially recruits small RNAs with a 5’ terminal cytosine. Probably involved in antiviral RNA silencing. Associates with siRNAs derived fro [...] (997 aa)
         
0.922
AGO1
Stabilizer of iron transporter SufD / Polynucleotidyl transferase; Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Requires DRB1 for directional loading of the small RNA duplex (guide stand and passenger strand) onto RISC for passenger strand degradation. Unlike animal RISC that associates in hig [...] (1050 aa)
         
0.922
AGO10
Stabilizer of iron transporter SufD / Polynucleotidyl transferase; Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Required for reliable formation of primary and axillary shoot apical meristems. Specifies leaf adaxial identity by repressing the miR165 and miR166 microRNAs in the embryonic shoot [...] (988 aa)
         
0.919
NRPB2
DNA-directed RNA polymerase family protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. NRPB2 is [...] (1188 aa)
         
  0.918
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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