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IWS1 protein (Arabidopsis thaliana) - STRING interaction network
"IWS1" - Transcription elongation factor in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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IWS1Transcription elongation factor (TFIIS) family protein; Transcription factor involved in RNA polymerase II (RNAPII) transcription regulation. Involved in transcription elongation. May function at post-recruitment and elongation steps of transcription. May be recruited by BZR2/BES1 to target genes and promote their expression during transcription elongation process. Required for brassinosteroid (BR)-induced gene expression. Required the for regulation of numerous nitrogen-responsive genes in roots. Acts in roots to repress NRT2.1 transcription in response to high nitrogen supply. This r [...] (502 aa)    
Predicted Functional Partners:
GTB1
Transcription elongation factor SPT6 homolog; Transcription elongation factor that enhances the transcription elongation by RNA polymerase II (RNAPII) (By similarity). Plays an important role in regulating embryo apical and basal patterning during early embryogenesis, partly through negative regulation of the transcription factors PHABULOSA and PHAVOLUTA (1647 aa)
     
 
  0.998
ELF8
Encodes a yeast CTR9 homolog that is involved in the control of flowering time by elevating FLC expression to a level that creates the vernalization-responsive, winter-annual habit. Yeast CTR9 is a component of a five-member PAF1 complex that associates with RNA pol II and is thought to regulate gene expression by recruiting SET1 (a histone 3 Lys 4 [H3-K4] methyl transferase) to the initially transcribed [5’] regions of target chromatin. Mutants display reduced H3-K4 methylation in both FLC and FLM chromatin (1091 aa)
     
 
  0.949
BES1
Brassinosteroid signalling positive regulator (BZR1) family protein; Positive regulator of brassinosteroid (BR) signaling. Transcription factor that activates target gene expression by binding specifically to the DNA sequence 5’-CANNTG-3’(E box) through its N-terminal domain. Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BIM1, BIM2 or BIM3. The C-terminal domain is probably involved in transcriptional activation. Recruits the transcription elongation factor IWS1 to control BR-regulated gene expression. Forms a trimeric complex with IWS1 a [...] (357 aa)
       
 
  0.939
AT1G63210
Transcription elongation factor SPT6-like; Transcription elongation factor that enhances the transcription elongation by RNA polymerase II (RNAPII) (1197 aa)
     
 
  0.936
EFS
Histone methyltransferases(H3-K4 specific);histone methyltransferases(H3-K36 specific); Histone methyltransferase involved in di and tri- methylation of ’Lys-36’ of histone H3 (H3K36me2 and H3K36me3). Binds to H3 already mono- or di-methylated on ’Lys-4’(H3K4me1 or H3K4me2), but not to H3K4me3. H3K4me and H3K36me represent specific tags for epigenetic transcriptional activation. Regulates positively FLC transcription to prevent early flowering transition. Required for flowering transition in response to vernalization and for the maintenance of FLC expression in late embryos, but dispen [...] (1805 aa)
     
 
  0.919
SPT16
Global transcription factor C; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishmen [...] (1074 aa)
     
 
  0.907
GTC2
GTC2; Homologous to yeast SPT16, a general chromatin factor required for transcription (343 aa)
     
 
  0.893
SPT42
Transcription elongation factor SPT4 homolog 2; May regulate transcription elongation by RNA polymerase II. May enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex (By similarity) (116 aa)
     
 
  0.874
HMG
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (646 aa)
     
 
  0.814
TFIIS
Encodes RNA polymerase II transcript elongation factor TFIIS. Complements yeast TFIIS mutation. Mutant plants display essentially normal development, but they flower slightly earlier than the wild type and show clearly reduced seed dormancy (378 aa)
     
 
  0.805
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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