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FU protein (Arabidopsis thaliana) - STRING interaction network
"FU" - The FUSED in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
FUThe FUSED (FU) gene belongs to Ser/Thr protein kinase family and has a key role in the hedgehog signaling pathway known to control cell proliferation and patterning in fruit flies and humans . Arabidopsis thaliana genome has a single Fu gene. Cytokinesis-defective mutants, which we named two-in-one (tio), result from mutations in Arabidopsis Fu. Phenotypic analysis of tio mutants reveals an essential role for TIO in conventional modes of cytokinesis in plant meristems and during male gametogenesis. TIO is tightly localized to the midline of the nascent phragmoplast and remains associat [...] (1322 aa)    
Predicted Functional Partners:
Phragmoplast-associated kinesin-related protein, putative; Plus-end directed kinesin-like motor enzyme that plays a critical role in the organization of phragmoplast microtubules during cytokinesis. Constitutes a signaling module in association with serine/threonine-protein kinase TIO that is required to support phragmoplast expansion and cell-plate growth in plant cells; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily (1313 aa)
Phragmoplast-associated kinesin-related protein 1; Plus-end directed kinesin-like motor enzyme that plays a critical role in the organization of phragmoplast microtubules during cytokinesis. Constitutes a signaling module in association with serine/threonine-protein kinase TIO that is required to support phragmoplast expansion and cell-plate growth in plant cells. Binds microtubules in an ATP-sensitive manner (1292 aa)
Kinesin motor family protein; Its function is described as microtubule motor activity, ATP binding; Involved in microtubule-based movement; Located in chloroplast; Expressed in 17 plant structures; Expressed during 9 growth stages; Contains the following InterPro domains- Kinesin-related protein (InterPro-IPR010544), Kinesin, motor domain (InterPro-IPR001752); BEST Arabidopsis thaliana protein match is- phragmoplast-associated kinesin-related protein, putative (TAIR-AT3G23670.1); Has 35666 Blast hits to 25760 proteins in 1172 species- Archae - 323; Bacteria - 1981; Metazoa - 18692; Fun [...] (1114 aa)
Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (1415 aa)
Targeting protein for XKLP2; Regulates prospindle assembly during late prophase and at the onset of mitosis, before nuclear envelope breakdown (NEB). Is exported from the nucleus shortly before NEB and organized into two polar crescents. After NEB, is progressively associated with the forming spindle. Probably mediates AUR1 activation and localization to spindle microtubules. Has a microtubule binding capability and is able to trigger microtubule assembly induced by RanGTP in a heterologous system. Not involved in phragmoplast assembly, nuclear envelope reformation, and cortical microt [...] (790 aa)
Protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein; Protein serine/threonine phosphatases;protein kinases;catalytics;cAMP-dependent protein kinase regulators;ATP binding;protein serine/threonine phosphatases; Its function is described as cAMP-dependent protein kinase regulator activity, protein kinase activity, protein serine/threonine phosphatase activity, catalytic activity, ATP binding; Involved in protein amino acid phosphorylation, protein amino acid dephosphorylation, N-terminal protein myristoylation, regulation of protein amino acid phosphoryl [...] (1094 aa)
DNA ligase-like protein; Unknown protein; Has 38228 Blast hits to 24529 proteins in 1168 species- Archae - 169; Bacteria - 4103; Metazoa - 14594; Fungi - 5866; Plants - 1861; Viruses - 317; Other Eukaryotes - 11318 (source- NCBI BLink) (784 aa)
Calcium-dependent lipid-binding (CaLB domain) family protein; Stimulates the GTPase/ATPase activities of Obg-like ATPases (By similarity). Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (By similarity) (174 aa)
TPX2 (targeting protein for Xklp2) protein family; Contains the following InterPro domains- Xklp2 targeting protein (InterPro-IPR009675); BEST Arabidopsis thaliana protein match is- targeting protein for XKLP2 (TAIR-AT1G03780.2); Has 137 Blast hits to 127 proteins in 18 species- Archae - 0; Bacteria - 0; Metazoa - 3; Fungi - 2; Plants - 130; Viruses - 0; Other Eukaryotes - 2 (source- NCBI BLink) (309 aa)
ATP binding microtubule motor family protein; Probable plus end-directed motor protein that functions in the NACK-PQR (ANP3-MKK6-MPK4) MAP kinase signaling pathway, which is essential for somatic cell cytokinesis, especially for the cell-plate formation and its expansion. May regulate the activity and the localization of ANP3, probably by association through the non-catalytic region of the kinase. Functionally redundant with NACK1 and essential to promote the progression of cytokinesis and for cellularization (formation of the cell plate) during microgametogenesis and megagametogenesis (938 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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