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AT1G50410 protein (Arabidopsis thaliana) - STRING interaction network
"AT1G50410" - SNF2 and helicase domain-containing protein in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AT1G50410SNF2 and helicase domain-containing protein; Probable helicase-like transcription factor involved in transcriptional gene silencing. Associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. May be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin (PubMed-25420628). Associates with SUVR2 and functions redundantly with FRG1. Required for the efficient methylation of a broad range of RdDM target loci (PubMed-25425661) (981 aa)    
Predicted Functional Partners:
SUVR2
Histone-lysine N-methyltransferase SUVR2; Probable inactive histone-lysine methyltransferase that acts as regulator of transctiptional gene silencing independently of histone H3K9 methylation. Contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. Forms a complex with SUVR1 and associates with the SNF2-related chromatin-remodeling proteins CHR19, CHR27, and CHR28, thereby mediating nucleosome positioning and transcriptional silencing. Does not possess histone-lysine methyltransferase activity in vitro, [...] (740 aa)
       
 
  0.947
CRH1
CRT1 Homologue 1; Mediator of defense signaling triggered by distinct classes of R proteins. Required during hypersensitive response (HR) that confers disease resistance to turnip crinkle virus (TCV) (PubMed-19704828). Contributes to resistance against Pseudomonas syringae and Hyaloperonospora arabidopsidis, at early stages prior to cytosolic calcium ions Ca(2+) accumulation (PubMed-20332379). Required for pathogen-associated molecular pattern (PAMP)- triggered immunity, basal resistance, non-host resistance and systemic acquired resistance (SAR) (PubMed-23250427). Involved in RNA-dire [...] (626 aa)
           
  0.670
IDN2
INVOLVED IN DE NOVO 2; Forms a complex with FDM1/IDNL1 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway (PubMed-22570638, PubMed-22592791) and downstream of small interfering RNA (siRNA) formation (PubMed-22810086). Required for de novo DNA methylation, siRNA accumulation and siRNA-mediated maintenance methylation (PubMed-19915591). Required for several post-transcriptional gene silencing pathways (PubMed-20059743). Binds double-stranded RNAs (dsRNAs) with 5’-overhangs through its XS domain (PubMed-19915 [...] (647 aa)
           
  0.670
UVH3
DNA repair protein UVH3; Putative single-stranded DNA endonuclease involved in nucleotide excision repair (NER) of UV- and oxidative damaged DNA. May make the 3’-incision step in NER. Seems to play a role in senescence program (1479 aa)
     
 
  0.621
THO2
THO complex subunit 2; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export (1823 aa)
     
      0.607
CMT2
Chromomethylase 2; May be involved in the CpXpG methylation and in gene silencing (1295 aa)
           
  0.607
FDM2
Factor of DNA methylation 2; Forms a complex with IDN2 and FDM1/IDNL1 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway (635 aa)
           
  0.603
UVH1
DNA repair endonuclease UVH1; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). Involved in repair of UV light, and probably oxidative damage. The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5’ to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. May mediate the induction of a DNA-damage sensitive cell-cycle checkpoint during the G2 phase (956 aa)
     
 
  0.567
FDM1
Factor of DNA methylation 1; Forms a complex with IDN2 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway (PubMed-22302148, PubMed-22757778, PubMed-22570638, PubMed-22592791). Required for de novo DNA methylation and 24 nucleotide small interfering RNA (siRNA) accumulation (PubMed-22570638). Binds unmethylated but not methylated DNAs through its coiled-coil domain (PubMed-22757778). May bind double- stranded RNAs (dsRNAs) with 5’-overhangs through its XS domain (PubMed-22302148, PubMed-22757778). However, [...] (634 aa)
           
  0.558
DMS11
DEFECTIVE IN MERISTEM SILENCING 11; Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing (PubMed-22560611, PubMed-23675613). Exhibits ATPase activity (PubMed-22560611). May also be involved in the regulation of chromatin architecture to maintain gene silencing (PubMed-22555433). Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity. Probably involved in DNA repair (By similarity) (663 aa)
           
  0.554
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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