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THFS protein (Arabidopsis thaliana) - STRING interaction network
"THFS" - 10-formyltetrahydrofolate synthetase in Arabidopsis thaliana
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
THFS10-formyltetrahydrofolate synthetase (THFS) mRNA, complete (634 aa)    
Predicted Functional Partners:
THY-2
Bifunctional dihydrofolate reductase-thymidylate synthase 2; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate- de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP; In the C-terminal section; belongs to the thymidylate synthase family (565 aa)
   
 
  0.989
THY-1
Bifunctional dihydrofolate reductase-thymidylate synthase 1; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate- de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP; In the C-terminal section; belongs to the thymidylate synthase family (519 aa)
   
 
  0.988
AT1G11860
Aminomethyltransferase, mitochondrial; The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family (408 aa)
   
 
  0.980
SHM1
Encodes a protein with mitochondrial serine hydroxymethyltransferase activity, which functions in the photorespiratory pathway, catalyzes the conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. Involved in controlling cell damage caused by abiotic stress, such as high light and salt and the hypersensitive defense response of plants; Belongs to the SHMT family (517 aa)
   
  0.977
SHM6
Serine hydroxymethyltransferase 6; Catalyzes the interconversion of serine and glycine; Belongs to the SHMT family (599 aa)
   
  0.967
SHM2
Encodes a protein with serine hydroxymethyltransferase activity which is thought to be localized in the mitochondrial matrix. SHM2 expression fails to rescue the conditional lethal phenotype of the shm1-1 mutant, defective in SHM1 (533 aa)
   
  0.963
SHM3
Serine hydroxymethyltransferase 3, chloroplastic; Catalyzes the interconversion of serine and glycine and directs the hydroxymethyl moiety of serine into the metabolic network of H4PteGlu(n)-bound one-carbon units; Belongs to the SHMT family (529 aa)
   
  0.958
EDA36
Pyridoxal phosphate (PLP)-dependent transferases superfamily protein; Catalyzes the interconversion of serine and glycine; Belongs to the SHMT family (470 aa)
   
  0.958
SHM7
Serine hydroxymethyltransferase 7; Catalyzes the interconversion of serine and glycine; Belongs to the SHMT family (598 aa)
   
  0.957
AT1G31220
Phosphoribosylglycinamide formyltransferase, chloroplastic; N10-formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase that catalyzes the conversion of phosphoribosyl glycineamide to phosphoribosyl N-formylglycineamide (292 aa)
   
 
  0.955
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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