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AT3G03580 protein (Arabidopsis thaliana) - STRING interaction network
"AT3G03580" - Tetratricopeptide repeat in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
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Gene Fusion
AT3G03580Tetratricopeptide repeat (TPR)-like superfamily protein; Contains the following InterPro domains- Pentatricopeptide repeat (InterPro-IPR002885); BEST Arabidopsis thaliana protein match is- Pentatricopeptide repeat (PPR) superfamily protein (TAIR-AT4G18750.1); Has 54534 Blast hits to 14239 proteins in 270 species- Archae - 2; Bacteria - 13; Metazoa - 57; Fungi - 143; Plants - 53473; Viruses - 0; Other Eukaryotes - 846 (source- NCBI BLink); Belongs to the PPR family. PCMP-H subfamily (882 aa)    
Predicted Functional Partners:
Transducin/WD40 repeat-like superfamily protein; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20 (By similarity) (339 aa)
Uncharacterized protein At3g26780/MDJ14_6; Phosphoglycerate mutase family protein; Its function is described as catalytic activity; Involved in N-terminal protein myristoylation, metabolic process; Located in cytosol, mitochondrion; Contains the following InterPro domains- Histidine phosphatase superfamily, clade-1 (InterPro-IPR013078), Uncharacterised conserved protein UCP036920, phosphoglycerate mutase, plant X4/Y4 (InterPro-IPR017070); BEST Arabidopsis thaliana protein match is- Phosphoglycerate mutase family protein (TAIR-AT1G12850.1); Has 3099 Blast hits to 3054 proteins in 1059 s [...] (399 aa)
Nucleotidyltransferase family protein; Maternal effect embryo arrest 44 (MEE44); Its function is described as nucleotidyltransferase activity; Involved in embryo development ending in seed dormancy; Contains the following InterPro domains- Nucleotidyl transferase domain (InterPro-IPR002934), PAP/25A-associated (InterPro-IPR002058); BEST Arabidopsis thaliana protein match is- Nucleotidyltransferase family protein (TAIR-AT5G53770.1); Has 30201 Blast hits to 17322 proteins in 780 species- Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukary [...] (1481 aa)
DNA mismatch repair protein MLH3; Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is [...] (1169 aa)
Nucleotidyltransferase family protein; UTP-RNA uridylyltransferase with a marked preference for uridine polymerization and a distributive activity for the first added nucleotides. Uridylates oligo(A)-tailed mRNAs to prevent 3’ to 5’ ribonucleotytic attacks. Can prevent the 3’ trimming of mRNAs still engaged on polysomes. Acts synergistically with HESO1 in unmethylated miRNA uridylation, leading to their degradation. URT1 and HESO1 prefer substrates with different 3’ end nucleotides and act cooperatively to tail different forms of the same miRNAs. URT1 and HESO1 act sequentially, with U [...] (764 aa)
26S proteasome regulatory subunit 7 homolog B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (620 aa)
ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (507 aa)
ATPase, F1 complex, alpha subunit protein; Its function is described as hydrogen ion transporting ATP synthase activity, rotational mechanism, poly(U) RNA binding, zinc ion binding; Involved in proton transport, ATP metabolic process, ATP synthesis coupled proton transport; Located in 7 components; Expressed in male gametophyte, juvenile leaf, cultured cell, leaf; Expressed during seedling growth, seed development stages; Contains the following InterPro domains- ATPase, F1 complex, alpha subunit (InterPro-IPR005294), ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro-IP [...] (777 aa)
Nucleotidyltransferase family protein; Uridylates small RNAs to trigger their degradation. Catalyzes the uridylation of 5’ fragments produced by AGO1-mediated cleavage of miRNA target RNAs. Acts synergistically with URT1 in unmethylated miRNA uridylation, leading to their degradation. URT1 and HESO1 prefer substrates with different 3’ end nucleotides and act cooperatively to tail different forms of the same miRNAs. URT1 and HESO1 act sequentially, with URT1 mono-uridylating the miRNAs followed by their further uridylation by HESO1. Able to act on AGO1-bound miRNAs and the uridylated sp [...] (511 aa)
Clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). Mediates endocytosis and is required for a correct polar distribution of PIN auxin transporters; Belongs to the clathrin heavy chain family (1705 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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