STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CHLI1Magnesium-chelatase subunit ChlI-1, chloroplastic; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. The magnesium-chelatase is a complex of three subunits, CHLI, CHLD and CHLH. The reaction takes place in two steps, with an ATP-dependent activation followed by an ATP-dependent chelation step. Possesses high affinity for ATP and may play a major role in chlorophyll biosynthesis. Does not bind abscisic acid (ABA), but is a positive regulator of ABA signaling. (424 aa)    
Predicted Functional Partners:
CHLH
Magnesium-chelatase subunit ChlH, chloroplastic; Multifunctional protein involved in chlorophyll synthesis, plastid-to-nucleus retrograde signaling and abscisic acid (ABA) perception. In chlorophyll synthesis, catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. The reaction takes place in two steps, with an ATP-dependent activation followed by an ATP-dependent chelation step. In addition to its function in the Mg-chelatase enzyme, is required for the plastid-to- nucleus retrograde signaling. The plastid-to-nucleus signal plays an important rol [...]
 
 
 0.999
CHLM
Magnesium protoporphyrin IX methyltransferase, chloroplastic; Converts Mg-protoporphyrin IX to Mg-protoporphyrin IX methylester using S-adenosyl-L-methionine as a cofactor. Involved in chloroplast-to-nucleus signaling by acting as a negative effector of nuclear photosynthetic gene expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. Magnesium protoporphyrin O-methyltransferase family.
 
 
 0.997
CHLD
Magnesium-chelatase subunit ChlD, chloroplastic; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. The magnesium-chelatase is a complex of three subunits, CHLI, CHLD and CHLH. The reaction takes place in two steps, with an ATP-dependent activation followed by an ATP-dependent chelation step. Does not bind abscisic acid; Belongs to the Mg-chelatase subunits D/I family.
 
 
0.983
PPOX1
Protoporphyrinogen oxidase 1, chloroplastic; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
   
 
 0.981
PPOX2
Protoporphyrinogen oxidase 2, chloroplastic/mitochondrial; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
   
 
 0.977
FC1
Ferrochelatase-1, chloroplastic/mitochondrial; Catalyzes the last step of heme biosynthesis by inserting ferrous iron into protoporphyrin IX to produce protoheme. Produces heme for photosynthetic cytochromes, but does not seem to be involved in stress responses. May be involved in wound-induced supply of heme to defensive hemoproteins outside plastids. Regulates the expression of photosynthesis-associated nuclear genes in undevelopped chloroplasts through production of heme.
    
 0.962
FC2
Ferrochelatase-2, chloroplastic; Catalyzes the last step of heme biosynthesis by inserting ferrous iron into protoporphyrin IX to produce protoheme. Produces heme for photosynthetic cytochromes, and for proteins involved in abiotic and biotic stress responses. May play a role in the quality control of individual chloroplasts during photo-oxidative stress through regulation of heme biosynthesis. Belongs to the ferrochelatase family.
  
 
 0.956
CHLP
Geranylgeranyl diphosphate reductase, chloroplastic; Catalyzes the reduction of geranylgeranyl diphosphate to phytyl diphosphate, providing phytol for both tocopherol and chlorophyll synthesis; Belongs to the geranylgeranyl reductase family. ChlP subfamily.
  
  
 0.952
CHLI2
Magnesium-chelatase subunit ChlI-2, chloroplastic; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. The reaction takes place in two steps, with an ATP-dependent activation followed by an ATP-dependent chelation step. Possesses low affinity for ATP and may play a limited role in chlorophyll biosynthesis, and contributes to the assembly of the Mg-chelatase complex.
  
 
0.945
EDA40
Probable E3 ubiquitin-protein ligase EDA40; Probable E3 ubiquitin-protein ligase involved in female gametophyte development. Required for fusion of polar nuclei in the embryo sac.
  
 0.934
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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