STRINGSTRING
At4g35830 protein (Arabidopsis thaliana) - STRING interaction network
"At4g35830" - Aconitate hydratase 1 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
At4g35830Aconitate hydratase 1; Encodes an aconitase that can catalyze the conversion of citrate to isocitrate through a cis-aconitate intermediate, indicating that it may participate in the TCA cycle and other primary metabolic pathways. The protein is believed to accumulate in the mitochondria and the cytosol. It affects CSD2 (At2g28190 - a superoxide dismutase) transcript levels and may play a role in the response to oxidative stress. This enzyme can also specifically bind to the 5’ UTR of CSD2 in vitro; Belongs to the aconitase/IPM isomerase family (898 aa)    
Predicted Functional Partners:
ICDH
Peroxisomal isocitrate dehydrogenase [NADP]; May be involved in response to oxidative stresses; Belongs to the isocitrate and isopropylmalate dehydrogenases family (416 aa)
   
  0.984
cICDH
Cytosolic NADP+-dependent isocitrate dehydrogenase; May supply 2-oxoglutarate for amino acid biosynthesis and ammonia assimilation via the glutamine synthetase/glutamate synthase (GS/GOGAT) pathway. May be involved in the production of NADPH to promote redox signaling or homeostasis in response to oxidative stress (410 aa)
   
  0.967
AT5G14590
Isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial; May be involved in response to oxidative stresses; Belongs to the isocitrate and isopropylmalate dehydrogenases family (485 aa)
   
  0.959
ATCS
Encodes a mitochrondrion targeted citrate synthase, the first enzyme of the tricarboxylic acid cycle, catalyzing the condensation of acetyl-CoA and oxaloacetate, finally yielding citrate and CoA (474 aa)
 
  0.958
CSY3
Citrate synthase 3, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria (509 aa)
 
  0.958
ICL
Isocitrate lyase; Involved in storage lipid mobilization during the growth of higher plant seedling; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family (576 aa)
   
  0.956
CSY5
Citrate synthase 5 (CSY5); Its function is described as citrate (SI)-synthase activity, transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer; Involved in cellular carbohydrate metabolic process, tricarboxylic acid cycle; Located in mitochondrion; Expressed in 8 plant structures; Expressed during M germinated pollen stage, 4 anthesis, 4 leaf senescence stage, petal differentiation and expansion stage; Contains the following InterPro domains- Citrate synthase-like, large alpha subdomain (InterPro-IPR016142), Citrate synthase, eukaryotic (InterPro-I [...] (464 aa)
 
  0.952
CSY2
Citrate synthase 2, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria (514 aa)
 
  0.944
CSY1
Encodes a peroxisomal citrate synthase that is expressed in siliques and developing seeds; Belongs to the citrate synthase family (480 aa)
 
  0.914
IDH1
Encodes a regulatory subunit of the mitochondrially-localized NAD+- dependent isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family (367 aa)
   
  0.911
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (11%) [HD]