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ATR protein (Arabidopsis thaliana) - STRING interaction network
"ATR" - Ataxia telangiectasia-mutated and RAD3-related in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ATRAtaxia telangiectasia-mutated and RAD3-related; Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2-arrest response to double-strand breaks. May also be involved in the me [...] (2702 aa)    
Predicted Functional Partners:
ATRAD17
Cell cycle checkpoint protein RAD17; Seems to be involved in regulation of DNA repair correlated to non-homologous double strand breaks (DSBs) repair. In vitro, involved in rapid but not in slow DSB repair mechanism. Required for effective immune responses that involve activation of DNA damage responses (599 aa)
     
 
  0.992
MRE11
Double-strand break repair protein MRE11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand- specific 3’-5’ exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family (720 aa)
     
 
  0.985
RAD50
DNA repair-recombination protein (RAD50); Implicated in double-strand breaks (DSBs) repair by non- homologous end joining (NHEJ). Involved in telomere maintenance. Involved in telomerase action on chromosome ends. Required during meiosis for both male and female gametophytic development, for pairing and synapsis of homologous chromosomes during the early stages of meiotic recombination, especially during the pachytene stage of the first division; Belongs to the SMC family. RAD50 subfamily (1316 aa)
     
 
  0.984
REV3
Encodes the catalytic subunit of DNA polymerase zeta.Mutants are sensitive to UV-B radiation. Gene is involved in damage-tolerance mechanisms through translesion synthesis(TLS) (1916 aa)
     
 
  0.984
NBS1
Nijmegen breakage syndrome 1 protein; Component of the MRE11-RAD50-NBN complex (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex may be involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, and cell cycle checkpoint control. Functions also in the very early stages of meiosis (542 aa)
     
 
  0.973
RAD9
Cell cycle checkpoint control protein family; Involved in the regulation of DNA damage repair and homologous recombination (456 aa)
     
 
  0.973
RAD51
RAS associated with diabetes protein 51; Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Unwinds duplex DNA (By similarity). Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) generated by AtSPO11-1 and in homologous recombination. Its function is dispensable for vegetative growth and root mitosis (342 aa)
       
 
  0.969
SRS2
P-loop containing nucleoside triphosphate hydrolases superfamily protein; Encodes a homolog of the yeast SRS2 (Suppressor of RAD Six-screen mutant 2) helicase. The Arabidopsis SRS2 is a functional 3- to 5-helicase. Biochemical studies show that SRS2 disrupts recombinogenic DNA intermediates and facilitates single strand annealing (1149 aa)
     
 
  0.967
KU70
ATP-dependent DNA helicase 2 subunit KU70; Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU80, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Required for maintenance of the telomeric C-rich strand; Belongs to the ku70 family (621 aa)
       
 
  0.967
UVH1
Restriction endonuclease, type II-like superfamily protein; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). Involved in repair of UV light, and probably oxidative damage. The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5’ to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. May mediate the induction of a DNA-damage sensitive cell-cycle checkpoint during the G2 phase (956 aa)
     
 
  0.966
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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