STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECT3YTH domain-containing protein ECT3; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and regulates mRNA stability (Probable). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (Probable). Required for the correct timing of leaf formation and normal leaf morphology. Required for proper trichome branching and morphology. Functions redundantly with ECT2. (495 aa)    
Predicted Functional Partners:
FIP37
FKBP12-interacting protein of 37 kDa; Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especia [...]
   
  
 0.922
ALKBH10B
RNA demethylase ALKBH10B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. ALKBH10B-mediated mRNA m6A demethylation stabilizes the mRNA of the key flowering time regulators FT, SPL3 and SPL9, which are involved in the control of floral transition.
      
 0.902
MTA
N6-adenosine-methyltransferase MT-A70-like; Catalytic subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTB, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. Belongs to the MT-A70-like family.
  
  
 0.895
HAKAI
E3 ubiquitin-protein ligase HAKAI homolog; Probable E3 ubiquitin-protein ligase which is a subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, FIP37 and VIR to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing.
      
 0.886
MTB
N6-adenosine-methyltransferase non-catalytic subunit MTB; Probable non-catalytic subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing.
  
  
 0.885
VIR
Protein virilizer homolog; Subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'- [AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, FIP37 and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing.
    
 
 0.833
ALKBH9B
RNA demethylase ALKBH9B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Modulates viral infection of the alfalfa mosaic virus (AMV) and the m6A abundance in its genomic RNAs.
      
 0.831
ALKBH8
Alkylated DNA repair protein ALKBH8 homolog; Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine. Belongs to the alkB family.
      
 0.801
ARPC2A
Actin-related protein 2/3 complex subunit 2A; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development; Belongs to the ARPC2 family.
      
 0.759
F9F13.6
Oxidoreductase.
      
 0.758
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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