STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYP710A2Cytochrome P450 710A2; Required to form the C-22 double bond in the sterol side chain. Possesses in vitro C-22 desaturase activity toward 24-epi- campesterol and beta-sitosterol and produces brassicasterol and stigmasterol, respectively. No activity with campesterol. (499 aa)    
Predicted Functional Partners:
DIM
Delta(24)-sterol reductase; Plays a critical role in the general process of plant cell elongation. Involved in the synthesis of campesterol, an early precursor of brassinolide. Required for the conversion of 24- methylenecholesterol to campesterol and for the conversion of isofucosterol to sitosterol. Necessary for both the isomerization and reduction of 24-methylenecholesterol. Regulates indirectly phytochrome- mediated light responses through the modulation of brassinosteroid biosynthesis.
     
 0.953
CPI1
Cycloeucalenol cycloisomerase; Converts pentacyclic cyclopropyl sterols to tetracyclic sterols.
     
 0.863
SMT2
24-methylenesterol C-methyltransferase 2; Catalyzes the methyl transfer from S-adenosyl-methionine to the methylene group of 24-methylene lophenol to form 24-ethylidene lophenol.
    
 0.838
FK
Delta(14)-sterol reductase; Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta- 8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. Required for cell division and expansion and is involved in proper organization of the embryo.
    
 0.835
SMO2-1
Methylsterol monooxygenase 2-1; Non-heme iron oxygenase involved in sterols biosynthesis. 24- ethylidenelophenol and 24-ethyllophenol are the preferred substrates.
   
 0.825
SMO2-2
Methylsterol monooxygenase 2-2; Non-heme iron oxygenase involved in sterols biosynthesis. 24- ethylidenelophenol and 24-ethyllophenol are the preferred substrates.
   
 0.817
LAS1
Lanosterol synthase; Converts oxidosqualene to lanosterol. Belongs to the terpene cyclase/mutase family.
    
 0.807
CAS1
Cycloartenol synthase; Converts oxidosqualene to cycloartenol and 1% parkeol. Involved in plastid biogenesis. Essential for the male gametophyte function; Belongs to the terpene cyclase/mutase family.
    
 0.806
SMT1
Cycloartenol-C-24-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
    
 0.804
STE1
Delta(7)-sterol-C5(6)-desaturase 1; Involved in the biosynthesis of sitosterol and campesterol, a precursor of growth-promoting brassinosteroids.
   
 0.800
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.