STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VPS53Vacuolar protein sorting-associated protein 53 A; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity). Required for vesicle trafficking involved in plasma membrane protein composition. Probably involved in pollen tube elongation and other polar growth. Confers basal tolerance to long-term heat stress and osmotic stress, by acclimation of the plasma membrane. Belongs to the VPS53 family. (828 aa)    
Predicted Functional Partners:
VPS54
Vacuolar protein sorting-associated protein 54, chloroplastic; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity). Probably involved in pollen tube elongation and other polar growth; Belongs to the VPS54 family.
   
 0.999
VPS51
Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome- derived carriers to the TGN. Acts as component of the EARP complex [...]
   
 0.999
VPS52
Vacuolar protein sorting-associated protein 52 A; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity). Required for pollen tube elongation and other polar growth; Belongs to the VPS52 family.
   
 0.999
T1E2.18
Coiled-coil protein.
   
 
 0.994
COG4
Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function.
   
 
 0.989
P2-2
Vacuolar protein sorting-associated protein 52 B; May be involved in retrograde transport of early and late endosomes to the late Golgi; Belongs to the VPS52 family.
   
 0.986
COG8
Conserved oligomeric Golgi complex subunit 8; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. Involved in pollen tube growth by modulating Golgi morphology and vesicle trafficking homeostasis leading to the deposition of cell wall components and proteins at the pollen tube tip. Required for sporophytic development. Belongs to the COG8 family.
   
 
 0.976
COG3
Conserved oligomeric Golgi complex subunit 3; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. Involved in pollen tube growth by modulating Golgi morphology and vesicle trafficking homeostasis leading to the deposition of cell wall components and proteins at the pollen tube tip. Required for sporophytic development. Belongs to the COG3 family.
   
 
 0.972
COG6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
   
 
 0.971
COG2
Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function (By similarity). Ensures, when in complex with FPP3/VETH1 and FPP2/VETH2, the correct secondary cell wall (SCW) deposition pattern by recruiting exocyst components to cortical microtubules in xylem cells during secondary cell wall deposition.
   
 
 0.956
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.