STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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[Homology]
Score
AHLPAP-specific phosphatase HAL2-like; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS (By similarity). Prevents both the toxicity of PAP on RNA processing enzymes as well as the product inhibition by PAP of sulfate conjugation; Belongs to the inositol monophosphatase superfamily. (373 aa)    
Predicted Functional Partners:
APR1
5'-adenylylsulfate reductase 1, chloroplastic; Reduces sulfate for Cys biosynthesis. Substrate preference is adenosine-5'-phosphosulfate (APS) >> 3'-phosphoadenosine-5'- phosphosulfate (PAPS). Uses glutathione or DTT as source of protons.
  
 
 0.959
APR3
5'-adenylylsulfate reductase 3, chloroplastic; Reduces sulfate for Cys biosynthesis. Substrate preference is adenosine-5'-phosphosulfate (APS) >> 3'-phosphoadenosine-5'- phosphosulfate (PAPS). Uses glutathione or DTT as source of protons.
  
 
 0.950
APR2
5'-adenylylsulfate reductase 2, chloroplastic; Reduces sulfate for Cys biosynthesis. Substrate preference is adenosine-5'-phosphosulfate (APS) >> 3'-phosphoadenosine-5'- phosphosulfate (PAPS). Uses glutathione or DTT as source of protons.
  
 
 0.950
HINT4
Bifunctional adenosine 5'-phosphosulfate phosphorylase/adenylylsulfatase HINT4; Possesses adenylylsulfatase activity in vitro, releasing AMP and sulfate from adenylyl sulfate. Possesses also adenosine 5'- phosphosulfate (APS) phosphorylase activity in vitro. Catalyzes the phosphorolysis of APS, leading to ADP and sulfate.
     
  0.900
SIR
Assimilatory sulfite reductase (ferredoxin), chloroplastic; Essential protein with sulfite reductase activity required in assimilatory sulfate reduction pathway during both primary and secondary metabolism and thus involved in development and growth. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
  
 0.816
Q56YY9_ARATH
At3g27906.
      
 0.794
T15P17.7
Probable eukaryotic translation initiation factor 5-1; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity).
      
 0.785
APK1
Adenylyl-sulfate kinase 1, chloroplastic; Catalyzes the synthesis of activated sulfate. Essential for plant reproduction and viability. Required for the production of glucosinolates.
  
 
 0.782
APS1-2
ATP sulfurylase 1, chloroplastic; Mediates selenate (Se) reduction, and promotes Se and sulfur (S) uptake and assimilation; Belongs to the sulfate adenylyltransferase family.
  
 
 0.771
APS3
ATP-sulfurylase 3, chloroplastic.
  
 
 0.740
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.