STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MIEL1E3 ubiquitin-protein ligase MIEL1; E3 ubiquitin-protein ligase that acts as a regulator of cell death and defense. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Attenuates the activation of defense and related cell death responses in the absence of pathogens by mediating ubiquitination and subsequent proteasomal degradation of MYB30. (267 aa)    
Predicted Functional Partners:
MYB30
Transcription factor MYB30; Transcription factor that binds specifically to the DNA sequence 5'-AACAAAC-3'. Acts as a positive regulator of hypersensitive cell death. Acts as a positive regulator of salicylic acid synthesis. Regulates very-long-chain fatty acid biosynthesis. Acts cooperatively with BZR2 to promote expression of a subset of brassinosteroids target genes. Transcriptional activity and hypersensitive response control negatively regulated by PLA2-ALPHA and by the Xanthomonas type III effector XopD (AC G9L9K6). Involved in the regulation of abscisic acid (ABA) signaling. Inc [...]
   
  
 0.909
PI4KG2
Phosphatidylinositol 4-kinase gamma 2; The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5- bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3); Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
    
 0.833
MYB96
Transcription factor MYB96; Transcription activator involved in the activation of cuticular wax biosynthesis under drought stress. Binds directly to DNA consensus sequences found in the promoters of genes encoding very-long- chain fatty acid-condensing enzymes involved in cuticular wax biosynthesis. Functions together with MYB94 in the activation of cuticular wax biosynthesis. Involved in drought stress response through abscisic acid (ABA) signaling. Mediates ABA signals that enhance plant resistance to drought by reducing stomatal opening. Mediates ABA-auxin cross-talk to regulate lat [...]
      
 0.796
RHA2B
E3 ubiquitin-protein ligase RHA2B; E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid (ABA) signaling and responses to salt and osmotic stresses during seed germination and early seedling development. Acts additively with RHA2A in regulating ABA signaling and drought response. Possesses E3 ubiquitin ligase activity in vitro.
     
 0.792
MPN9.19
E3 ubiquitin-protein ligase RING1-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Promotes polyubiquitination of target proteins.
   
 
 0.720
RHB1A
Probable E3 ubiquitin-protein ligase RHB1A; Probable E3 ubiquitin-protein ligase that may possess E3 ubiquitin ligase activity in vitro.
     
 0.698
POLH
DNA polymerase eta; Error-free DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis (TLS), where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers and confers resistance to ultraviolet light. Depending on the context, it inserts the correct base, but may cause base transitions and transversions. Forms a Schiff base with 5'- deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Exhibits [...]
    
 0.691
T26J12.6
Uncharacterized protein.
      
 0.651
PLA2-ALPHA
Phospholipase A2-alpha; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli. Modulates the trafficking of PIN proteins to the plasma membrane. Negatively regulates MYB30 transcriptional activity and hypersensitive response control.
      
 0.600
F15H11.2
AT1G70770 protein.
      
 0.573
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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