STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABCC1ABC transporter C family member 1; Pump for glutathione S-conjugates. Mediates the transport of S-(2,4-dinitrophenyl)-glutathione (DNP-GS), GSSG, cyanidin 3-glucoside- GS (C3G-GS) and metolachlor-GS (MOC-GS); Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. (1622 aa)    
Predicted Functional Partners:
PCS1-2
Glutathione gamma-glutamylcysteinyltransferase 1; Involved in the synthesis of phytochelatins (PC) and homophytochelatins (hPC), the heavy-metal-binding peptides of plants. Also involved in glutathione-conjugates degradation.
      
 0.899
HMA4
Putative cadmium/zinc-transporting ATPase HMA4; Involved in cadmium/zinc transport; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
  
  
 0.799
CAX4
Vacuolar cation/proton exchanger 4; Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+) and other metal ions into vacuoles using the proton gradient formed by H(+)-ATPase and H(+)-pyrophosphatase. Cation selectivity transport in tobacco root tonoplast vesicles is Cd(2+)>Zn(2+)>>Ca(2+)>>>Mn(2+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/proton exchanger (CAX) subfamily.
      
 0.794
Dl3235W
Ankyrin repeat family protein.
    
 0.791
NRAMP1
Metal transporter Nramp1; High affinity manganese (Mn) transporter involved in Mn acquisition from the soil. Required for Mn uptake into the root in conditions of low Mn availability. Can transport iron (Fe), cadmium (Cd) and cobalt (Co).
   
  
 0.774
NRAMP3
Metal transporter Nramp3; Vacuolar metal transporter involved in intracellular metal homeostasis. Can transport iron (Fe), manganese (Mn) and cadmium (Cd). Regulates metal accumulation under Fe starvation. Acts redundantly with NRAMP4 to mobilize vacuolar Fe and provide sufficient Fe during seed germination. In association with NRAMP4, required for optimal growth and photosynthesis under Mn deficiency. Exports Mn from vacuoles in leaf mesophyll cells, making Mn available for functional photosystem II in chloroplasts. Involved in basal resistance to the bacterial pathogen E.chrysanthemi.
      
 0.761
HMA3
Putative inactive cadmium/zinc-transporting ATPase HMA3.
  
  
 0.746
ABCG40
ABC transporter G family member 40; May be a general defense protein (By similarity). Functions as a pump to exclude Pb(2+) ions and/or Pb(2+)-containing toxic compounds from the cytoplasm. Contributes to Pb(2+) ions resistance. Confers some resistance to the terpene sclareol.
   
 0.737
HMA2
Cadmium/zinc-transporting ATPase HMA2; Plays an important role in zinc transport and homeostasis. Could also be involved in cadmium detoxification.
  
  
 0.725
OPT6
Oligopeptide transporter 6; Involved in the translocation of tetra- and pentapeptides across the cellular membrane in an energy-dependent manner. Also involved in transport of glutathione derivatives and metal complexes, and may be involved in stress resistance.
      
 0.720
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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