STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
DCI1Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, peroxisomal; Converts 3,5-dienoyl-CoAs to the corresponding 2,4-dienoyl- CoAs. Involved in degradation of unsaturated fatty acids. (278 aa)    
Predicted Functional Partners:
PEX5
Peroxisome biogenesis protein 5; Import receptor for peroxisomal-targeting signal one (PTS1). A receptor-cargo complex composed of PEX5, PEX7, a PTS1-containing protein and a PTS2-containing protein is targeted to peroxisomes during import. Necessary for the developmental elimination of obsolete peroxisome matrix proteins.
    
 0.942
PEX10
Peroxisome biogenesis factor 10; Involved in the formation of peroxisomes, lipid bodies and protein bodies. Required for normal-shaped peroxisomes that can physically associate with the outer membrane of the chloroplast envelope. Not involved in beta-oxidation and glyoxylate cycle. Acts as an E3 ubiquitin-protein ligase. Belongs to the pex2/pex10/pex12 family.
     
 0.840
PEX12
Peroxisome biogenesis protein 12; Required for peroxisome biogenesis and for PTS1- and PTS2- dependent protein import into peroxisomes. Essential for the peroxisomal targeting of PEX7. Required for the export/release of receptors on the peroxisome membrane. Acts as an E3 ubiquitin-protein ligase involved in monoubiquitination of PEX5.
   
 
 0.816
T1A4.20
Alpha/beta-Hydrolases superfamily protein.
   
  
 0.795
GPDHC1
Glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1, cytosolic; Involved in cell redox homeostasis. Required for maintaining a steady state cellular NADH/NAD(+) ratio through a mitochondrial glycerol-3-phosphate redox shuttle. May function with the mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase SDP6 to shuttle reducing equivalents into the mitochondria for respiration.
      
 0.746
PEX14
Peroxisomal membrane protein PEX14; Controls intracellular transport of both PTS1- and PTS2- containing proteins. Required for the proper targeting of PEX7 to the peroxisome.
    
 0.746
ECH2
Enoyl-CoA hydratase 2, peroxisomal; Bidirectional monofunctional enoyl-CoA hydratase 2 involved in the degradation of even cis-unsaturated fatty acids. Devoid of 3- hydroxyacyl-CoA dehydrogenase activity.
   
 0.741
SCP2
Sterol carrier protein 2; Enhances the transfer of lipids between membranes in vitro. Active on phosphatidylcholine (PC), 1-palmitoyl 2- oleoyl phosphatidylcholine (POPC) and ergosterol, and, to a lower extent, dimyristoyl phosphatidic acid, stigmasterol, desmosterol, beta- sitosterol and steryl glucoside. Inactive or poorly active on palmitic acid, stearoyl-coenzyme A, cholesterol, glucosylceramide and ceramide. Required during seeds and seedlings development.
   
 0.734
Q9FJI2_ARATH
Hydroxyacyl-thioester dehydratase type-like protein.
   
 0.730
LTA2
Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
      
 0.716
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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