STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
L2HGDHL-2-hydroxyglutarate dehydrogenase, mitochondrial; Catalyzes the oxidation of (S)-2-hydroxyglutarate to 2- oxoglutarate. Is specific for the (S) enantiomer and possesses very poor activity toward (R)-2-hydroxyglutarate. Has no activity toward related 2-hydroxy acids, such as glycolate, L-lactate or D-lactate. Belongs to the L2HGDH family. (483 aa)    
Predicted Functional Partners:
ETFQO
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. May act downstream of IVD and D2HGDH in the degradation of phytol or chlorophyll during dark-induced senescence and sugar starvation. Belongs to the ETF-QO/FixC family.
      
 0.928
IVD
Isovaleryl-CoA dehydrogenase, mitochondrial; Involved in degradation of the branched-chain amino acids, phytol and lysine for the supply of carbon and electrons to the ETF/ETFQO complex during dark-induced sugar starvation. Belongs to the acyl-CoA dehydrogenase family.
  
  
 0.912
GAD1
Glutamate decarboxylase 1; Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis. Belongs to the group II decarboxylase family.
     
 0.879
VPS52
Vacuolar protein sorting-associated protein 52 A; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity). Required for pollen tube elongation and other polar growth; Belongs to the VPS52 family.
 
      0.879
P2-2
Vacuolar protein sorting-associated protein 52 B; May be involved in retrograde transport of early and late endosomes to the late Golgi; Belongs to the VPS52 family.
 
      0.878
ALDH12A1
Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial; Plays a role in the inhibition of programmed cell death by converting the toxic proline catabolism intermediate (s)-1-pyrroline-5- carboxylate (P5C) to glutamate; Belongs to the aldehyde dehydrogenase family.
  
 
 0.876
F19C24.7
Amino acid dehydrogenase family protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.866
GDH2-2
Glutamate dehydrogenase 2; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
    
 0.864
GDH1-2
Glutamate dehydrogenase 1; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
    
 0.864
GSH3
Probable glutamate dehydrogenase 3; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
    
 0.864
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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