STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCO1Plant cysteine oxidase 1; Oxidizes N-terminal cysteine residues, thus preparing the protein for N-end rule pathway-mediated proteasomal degradation. Controls the preparation of ERF-VII proteins for degradation via the 26S proteasome. Not active on Cys located inside or at the C-terminus of a peptide. Represses the anaerobic response. (293 aa)    
Predicted Functional Partners:
PRT6
E3 ubiquitin-protein ligase PRT6; Ubiquitin protein ligase which is a component of the N-end rule pathway with arginine specificity, and functions with the arginyltransferases ATE1 and ATE2. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Does not participate in degradation of proteins with N-terminal Phe or Leu. The N-end rule pathway regulates seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity [...]
      
 0.926
HRA1
Sequence-specific DNA binding transcription factor.
   
  
 0.882
ATE2
Arginyl-tRNA--protein transferase 2; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Component of the N-end rule pathway with ATE1 and PRT6. The N-end rule pathway regulates seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination. The end-rule pathway regulates various aspects of leaf and shoot development. Involved in the oxygen-dependent N-arginylation of RAP2-12, [...]
      
 0.881
RAP2-12
Ethylene-responsive transcription factor RAP2-12; Transcription factor involved in the activation of hypoxic gene expression and in ethylene response. Partially redundant with RAP2-2. Acts as a downstream regulator in the ethylene signaling pathway; Belongs to the AP2/ERF transcription factor family. ERF subfamily.
      
 0.881
LBD41
LOB domain-containing protein 41.
   
  
 0.880
AHB1
Non-symbiotic hemoglobin 1; May not function as an oxygen storage or transport protein, but might act as an oxygen sensor or play a role in electron transfer, possibly to a bound oxygen molecule. Has an unusually high affinity for O(2) because of a very low dissociation constant; Belongs to the plant globin family.
   
  
 0.867
STR17
Rhodanese-like domain-containing protein 17.
   
  
 0.844
T16L1.50
Wound-responsive family protein.
   
  
 0.844
Q8L9T9_ARATH
At5g66985.
   
  
 0.844
PDC1
Pyruvate decarboxylase 1; May play a role in ethanolic fermentation during anoxia. Belongs to the TPP enzyme family.
   
  
 0.820
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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