STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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BCAT4Methionine aminotransferase BCAT4; Converts 2-oxo acids to branched-chain amino acids. Shows activity with L-Leu, L-Ile and L-Val as amino donors and alpha-keto- glutarate as an amino acceptor, but no activity for D-isomers of Leu, Ile, Val, Asp, Glu or Ala. Acts on methionine and its derivatives and the corresponding 2-oxo acids. Catalyzes the initial deamination of methionine to 4-methylthio-2-oxobutyrate as well as the transamination of other typical intermediates of the methionine chain elongation pathway. (354 aa)    
Predicted Functional Partners:
MAM1
Methylthioalkylmalate synthase 1, chloroplastic; Determines the side chain length of aliphatic glucosinolate structures. Catalyzes exclusively the condensation reactions of both the first and second methionine carbon chain elongation. Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.990
CYP83A1
Cytochrome P450 83A1; Involved in the metabolism of aliphatic and aromatic oximes. Involved in the biosynthesis of both short-chain and long-chain aliphatic glucosinolates. Belongs to the cytochrome P450 family.
   
 
 0.979
MAM3
Methylthioalkylmalate synthase 3, chloroplastic; Determines the side chain length of aliphatic glucosinolate structures. Accepts all the omega-methylthio-2-oxoalkanoic acids needed to form the known C3 to C8 glucosinolates. Also able to convert pyruvate to citramalate, 2-oxoisovalerate to isopropylmalate, 4-methyl- 2-oxopentanoate and 5-methyl-2-oxohexanoate for Leu-derived glucosinolates, 3-methyl-2-oxopentanoate for Ile-derived glucosinolates and phenylpyruvate to phenylethylglucosinolate. Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.979
SSU2
3-isopropylmalate dehydratase small subunit 2; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate (Probable). Functions redundantly with LEUD2 in the methionine chain elongation pathway of aliphatic glucosinolate formation.
  
  
 0.971
SSU3
3-isopropylmalate dehydratase small subunit 3; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate (Probable). Functions redundantly with LEUD1 in the methionine chain elongation pathway of aliphatic glucosinolate formation.
  
  
 0.970
IMDH1
3-isopropylmalate dehydrogenase 1, chloroplastic; Involved in both glucosinolate and leucine biosynthesis; catalyzes the oxidative decarboxylation step in both leucine biosynthesis (primary metabolism) and methionine chain elongation of glucosinolates (specialized metabolism). Catalyzes the oxidation of 3- carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate, 3-IPM) to 3- carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4- methyl-2 oxopentanoate. Required during pollen development and involved in embryo sac development. More active on 3-isopropylmalate and NAD(+) than [...]
  
 
 0.961
CYP79F1
Dihomomethionine N-hydroxylase; Catalyzes the conversion of the short chain elongated methionines di-, tri-, and tetrahomomethionine to their respective aldoximes 5-methylthiopentanaldoxime, 6-methylthiohexanaldoxime, and 7- methylheptanaldoxime.
   
 
 0.957
BASS5
Probable sodium/metabolite cotransporter BASS5, chloroplastic; Plastidic transporter involved in the biosynthesis of aliphatic glucosinolates by translocating the biosynthetic intermediates of Met-derived glucosinolates across chloroplast membranes. Transports short chain (C2) alpha-keto acids, such as 4- methylsulfanyl-2-oxobutanoic acid, from the cytosol to the chloroplast where they are subjected to chain elongation cycles. Functions also in the transport of chain-elongated (C3 to C8) Met derivatives from the chloroplast to the cytosol. Does not seem to be involved in the transport [...]
   
  
 0.953
SOT17
Cytosolic sulfotransferase 17; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of desulfo-glucosinolates (dsGSs), the final step in the biosynthesis of the glucosinolate core structure. Substrate preference is desulfo- benzyl glucosinolate > desulfo-6-methylthiohexyl glucosinolate. Increased specific activity with increasing chain length of desulfo- glucosinolate derived from methionine. Preferred substrate is desulfo- 8-methylthiooctyl glucosinolate.
   
  
 0.932
MYB28
Transcription factor MYB28; Major regulator of short-chained aliphatic glucosinolates (GLSs) biosynthesis. Together with MYB29/HAG3 and MYB76/HAG2, promotes aliphatic glucosinolate biosynthesis but represses indolic glucosinolate biosynthesis. Prevents insect performance (e.g. lepidopteran insect Mamestra brassicae and Spodoptera exigua) by promoting glucosinolates.
   
  
 0.924
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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