Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SirAPredicted redox protein; Regulator of disulfide bond formation; Belongs to the sulfur carrier protein TusA family. (79 aa)    
Predicted Functional Partners:
ThiF
Dinucleotide-utilizing enzymes; Involved in molybdopterin and thiamine biosynthesis family 2.
 
   
 0.872
DsrA
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
   
 0.868
SdhA
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit.
 
   
 0.773
PTH_0240
Ferredoxin.
 
   
 0.759
PTH_0245
Hypothetical protein; Containing OmpR response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain (COG0745).
  
    0.735
PTH_0246
Hypothetical protein; Containing BaeS signal transduction histidine kinase (COG0642).
       0.671
NifS
Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
   
 
 0.611
NifS-2
Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
   
 
 0.611
PTH_0577
Hypothetical protein; Containing DsrE (COG1553), uncharacterized conserved protein involved in intracellular sulfur reduction.
  
  
 0.610
CysC
Adenylylsulfate kinase and related kinases; Catalyzes the synthesis of activated sulfate.
  
  
 0.543
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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