Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ComECPredicted hydrolase; Metallo-beta-lactamase superfamily. (302 aa)    
Predicted Functional Partners:
GlyA
Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
      0.757
PTH_0566
Hypothetical protein.
       0.748
PTH_0565
Uncharacterized conserved protein.
       0.651
ComEB
Deoxycytidylate deaminase.
 
  
 0.628
PTH_0564
Hypothetical membrane protein.
       0.421
PTH_0568
Activator of 2-hydroxyglutaryl-CoA dehydratase; HSP70-class ATPase domain.
       0.407
PTH_1156
Hypothetical protein; Containing PulG (COG2165), type II secretory pathway, pseudopilin PulG and COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor.
  
  
 0.406
KsgA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
 
     0.403
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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