Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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ThiS-2Sulfur transfer protein; Involved in thiamine biosynthesis. (66 aa)    
Predicted Functional Partners:
ThiG
Uncharacterized enzyme; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.995
PTH_0642
Predicted dinucleotide-utilizing enzyme; ThiF/HesA family.
 
 0.990
ThiE
Thiamine monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.946
ThiC
Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.936
ThiH-3
Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.
 
    0.924
ThiS-3
Sulfur transfer protein; Involved in thiamine biosynthesis.
     
  0.900
ThiD
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
  
  
 0.840
ThiH-4
Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.
  
    0.587
ThiF
Dinucleotide-utilizing enzymes; Involved in molybdopterin and thiamine biosynthesis family 2.
  
 
 0.585
ThiF-2
Dinucleotide-utilizing enzymes; Involved in molybdopterin and thiamine biosynthesis family 2.
  
 
 0.585
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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