STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HgdB-2benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit; BcrC/BadD/HgdB. (325 aa)    
Predicted Functional Partners:
PTH_0789
Activator of 2-hydroxyglutaryl-CoA dehydratase; HSP70-class ATPase domain.
 
 0.992
ElaC
Metal-dependent hydrolases; Beta-lactamase superfamily III.
       0.790
NrdG
Organic radical activating enzymes; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
    0.728
PTH_0568
Activator of 2-hydroxyglutaryl-CoA dehydratase; HSP70-class ATPase domain.
 
 0.690
Rph
RNase PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
       0.640
PTH_1403
6-pyruvoyl-tetrahydropterin synthase.
 
    0.636
MurI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
       0.635
PTH_0792
Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
       0.620
PTH_1325
Activator of 2-hydroxyglutaryl-CoA dehydratase; HSP70-class ATPase domain.
 
 0.601
PTH_1234
Activator of 2-hydroxyglutaryl-CoA dehydratase; HSP70-class ATPase domain.
 
 0.596
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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