STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ElaCMetal-dependent hydrolases; Beta-lactamase superfamily III. (258 aa)    
Predicted Functional Partners:
PTH_0084
Hypothetical protein.
   
   0.841
Rph
RNase PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
  
  
 0.807
HgdB-2
benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit; BcrC/BadD/HgdB.
       0.790
PTH_0789
Activator of 2-hydroxyglutaryl-CoA dehydratase; HSP70-class ATPase domain.
       0.749
PTH_0792
Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
    0.741
PTH_0793
Predicted phosphoesterase.
 
     0.730
PTH_1236
Hypothetical protein; Containing COG0517and COG0617 domains; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
  
 0.680
PTH_0786
Hypothetical protein; Containing N-acetylmuramoyl-L-alanine amidase region (COG0860 AmiC) and SH3b domain.
 
 
   0.629
MurI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
       0.575
dinG
Hypothetical protein; 3'-5' exonuclease.
  
  
 0.472
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.