| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PTH_0926 | ThiD | PTH_0926 | PTH_0925 | Uncharacterized conserved protein. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | 0.778 |
| PTH_0926 | ychF | PTH_0926 | PTH_0927 | Uncharacterized conserved protein. | Predicted GTPase, probable translation factor; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.647 |
| ThiC | ThiD | PTH_0644 | PTH_0925 | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | 0.994 |
| ThiC | ThiE | PTH_0644 | PTH_0643 | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | Thiamine monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.992 |
| ThiC | ThiF-2 | PTH_0644 | PTH_0498 | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | Dinucleotide-utilizing enzymes; Involved in molybdopterin and thiamine biosynthesis family 2. | 0.619 |
| ThiC | ThiF-4 | PTH_0644 | PTH_2619 | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | Dinucleotide-utilizing enzymes; Involved in molybdopterin and thiamine biosynthesis family 2. | 0.599 |
| ThiC | ThiG | PTH_0644 | PTH_0640 | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | Uncharacterized enzyme; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.994 |
| ThiC | ThiS-2 | PTH_0644 | PTH_0639 | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | Sulfur transfer protein; Involved in thiamine biosynthesis. | 0.936 |
| ThiC | ThiS-3 | PTH_0644 | PTH_2898 | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | Sulfur transfer protein; Involved in thiamine biosynthesis. | 0.765 |
| ThiD | PTH_0926 | PTH_0925 | PTH_0926 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Uncharacterized conserved protein. | 0.778 |
| ThiD | ThiC | PTH_0925 | PTH_0644 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.994 |
| ThiD | ThiE | PTH_0925 | PTH_0643 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Thiamine monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
| ThiD | ThiF-2 | PTH_0925 | PTH_0498 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Dinucleotide-utilizing enzymes; Involved in molybdopterin and thiamine biosynthesis family 2. | 0.607 |
| ThiD | ThiF-4 | PTH_0925 | PTH_2619 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Dinucleotide-utilizing enzymes; Involved in molybdopterin and thiamine biosynthesis family 2. | 0.596 |
| ThiD | ThiG | PTH_0925 | PTH_0640 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Uncharacterized enzyme; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.861 |
| ThiD | ThiS-2 | PTH_0925 | PTH_0639 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Sulfur transfer protein; Involved in thiamine biosynthesis. | 0.840 |
| ThiD | ThiS-3 | PTH_0925 | PTH_2898 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Sulfur transfer protein; Involved in thiamine biosynthesis. | 0.736 |
| ThiD | TruA | PTH_0925 | PTH_0355 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Pseudouridylate synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.619 |
| ThiD | ychF | PTH_0925 | PTH_0927 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Predicted GTPase, probable translation factor; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.596 |
| ThiE | ThiC | PTH_0643 | PTH_0644 | Thiamine monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.992 |