STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTH_0952precorrin-6B methylase 1,2; Containing COG2241 and COG2242. (411 aa)    
Predicted Functional Partners:
cbiD
Cobalamin biosynthesis protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
  
 0.999
CobF
Precorrin-2 methylase; Belongs to the precorrin methyltransferase family.
  
 0.999
CobM
Precorrin-4 methylase; Belongs to the precorrin methyltransferase family.
  
 0.999
PTH_0956
precorrin-3B methylase and precorrin-6x reductase; COG1010, CobJ and COG2099, CobK.
  
 0.999
CobH
Precorrin isomerase; Containing CbiX domain.
 
 
 0.999
CbiG
Cobalamin biosynthesis protein CbiG.
 
  
 0.992
CobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.983
CobB
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
  
 0.974
CbiB
Cobalamin biosynthesis protein CobD/CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
  
 0.947
PTH_0973
uroporphyrinogen-III methylase and Uroporphyrinogen-III synthase; COG0007 CysG and COG1587 HemD.
 
  
 0.865
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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