STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (312 aa)    
Predicted Functional Partners:
HemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.999
PTH_0973
uroporphyrinogen-III methylase and Uroporphyrinogen-III synthase; COG0007 CysG and COG1587 HemD.
 0.999
HemB
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.999
CysG
Siroheme synthase; Precorrin-2 oxidase/ferrochelatase domain.
  
 0.993
HemL
Glutamate-1-semialdehyde aminotransferase.
  
 0.989
IspA
Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.
  
  
 0.869
CobM
Precorrin-4 methylase; Belongs to the precorrin methyltransferase family.
   
 0.862
PTH_0974
Predicted Fe-S oxidoreductases.
     
 0.860
PTH_0956
precorrin-3B methylase and precorrin-6x reductase; COG1010, CobJ and COG2099, CobK.
   
 0.773
CobH
Precorrin isomerase; Containing CbiX domain.
     
 0.748
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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