Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
BioB-3Biotin synthase and related enzymes. (359 aa)    
Predicted Functional Partners:
PTH_0982
Predicted GTPase.
   
 0.965
BirA
biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
 
 0.960
BioB-2
Biotin synthase and related enzymes; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
  
 
0.908
BioB
Biotin synthase and related enzymes.
  
  
 
0.905
PTH_0980
Hypothetical protein.
 
    0.892
ThiH-4
Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.
 
  
0.770
PTH_2010
NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit, chain G.
 
  
 0.754
PTH_0668
Iron only hydrogenase large subunit, C-terminal domain; Containig ferredoxin.
 
  
 0.750
PTH_1377
Hypothetical hydrogenase subunit; Containing COG3383, Uncharacterized anaerobic dehydrogenase, COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G).
 
  
 0.736
PTH_0520
Hypothetical membrane protein.
  
  
 0.659
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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