Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
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[Homology]
Score
PckAPhosphoenolpyruvate carboxykinase; ATP; Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (508 aa)    
Predicted Functional Partners:
PTH_1174
Hypothetical protein; Containing COG5016 and COG0511 domains.
  
 
 0.964
PykF
Pyruvate kinase; Belongs to the pyruvate kinase family.
     
 0.946
MmcK
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 
 0.938
PpsA
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family.
     
 0.927
PTH_2718
Hypothetical protein.
  
 
 0.918
PTH_2719
Hypothetical protein; Containing Eno (COG0148), Enolase.
  
 
 0.918
AspA
Aspartate ammonia-lyase.
   
 
 0.914
MmcM
Related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit.
    
 0.912
GltB-2
Glutamate synthase domain 2.
     
 0.907
GdhA
Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.883
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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