STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SmfPredicted Rossmann fold nucleotide-binding protein; Involved in DNA uptake. (367 aa)    
Predicted Functional Partners:
TopA
Topoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superco [...]
   
 0.942
PTH_1690
Predicted ATPase; With chaperone activity.
 
 0.941
ComEC-2
Predicted hydrolase; Metallo-beta-lactamase superfamily, containing predicted metal-binding region.
 
  
 0.905
ComFC
Predicted amidophosphoribosyltransferases.
 
 
 0.897
PulO
Type II secretory pathway, prepilin signal peptidase PulO and related peptidases; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
  
  
 0.734
PTH_1244
Predicted eukaryotic-type DNA primase.
       0.726
PTH_1707
Predicted endonuclease; Distantly related to archaeal holliday junction resolvase; Belongs to the UPF0102 family.
 
    0.720
FliY
Flagellum motor switch protein.
  
    0.715
PilT
Tfp pilus assembly protein; Pilus retraction ATPase PilT.
      
 0.700
PilT-2
Tfp pilus assembly protein, pilus retraction ATPase PilT.
      
 0.700
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.