STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LexA-2SOS-response transcriptional repressors; RecA-mediated autopeptidases. (224 aa)    
Predicted Functional Partners:
RecA
RecA/RadA recombinase; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.926
DinP
nucleotidyltransferase/DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.773
RecN
ATPase involved in DNA repair; May be involved in recombinational repair of damaged DNA.
   
  
 0.522
MmcD1
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
      
 0.520
MmcL
Transcarboxylase, 5S subunit; Pyruvate/oxaloacetate carboxyltransferase.
   
  
 0.511
dinG
Hypothetical protein; 3'-5' exonuclease.
  
  
 0.511
MmcE
methylmalonyl-CoA mutase, N-terminal domain/subunit.
      
 0.510
MmcF
methylmalonyl-CoA mutase, C-terminal domain/subunit; Cobalamin-binding.
      
 0.506
MmcC
Fumarase, C-terminal domain; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain.
      
 0.499
MmcD2
succinyl-CoA synthetase, alpha subunit.
      
 0.499
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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