STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ThrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (300 aa)    
Predicted Functional Partners:
ThrA
Homoserine dehydrogenase.
 
 0.999
ThrC
Threonine synthase.
 
 0.999
PurM
Phosphoribosylaminoimidazole (AIR) synthetase.
 
    
 0.916
MET2
Homoserine acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
     
 0.911
LysC-2
Aspartokinases; Belongs to the aspartokinase family.
  
 
 0.866
CysE
Serine acetyltransferase.
     
 0.856
IlvE
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.852
MET17
O-acetylhomoserine sulfhydrylase.
    
 0.814
SAM1
S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
   
 
  0.807
PheB
ACT domain-containing protein; Belongs to the UPF0735 family.
 
     0.780
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.