STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AddBATP-dependentnuclease subunitB; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity. (1157 aa)    
Predicted Functional Partners:
RecB
ATP-dependent exoDNAse (exonuclease V) beta subunit; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities; Belongs to the helicase family. AddA subfamily.
 
 
 0.999
SbcD
DNA repair exonuclease.
  
  
 0.734
PTH_0913
Predicted SAM-dependent methyltransferase.
 
     0.551
dinG
Hypothetical protein; 3'-5' exonuclease.
     
 0.464
PTH_1667
Predicted thioesterase.
       0.450
PTH_1043
Hypothetical protein; Containing RecJ, Single-stranded DNA-specific exonuclease domain (COG0608) and HELICc, Helicase superfamily c-terminal domain.
     
 0.442
RecF
Recombinational DNA repair ATPase; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
      
 0.418
RecO
Recombinational DNA repair protein; Involved in DNA repair and RecF pathway recombination.
      
 0.416
PTH_1996
Predicted HD-superfamily hydrolase.
 
     0.411
PTH_0914
Hyporthetical protein; Containing COG0327 and COG3323 domain; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
       0.403
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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