| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CdsA | PgsA | PTH_1258 | PTH_1297 | CDP-diglyceride synthetase; Belongs to the CDS family. | Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.946 |
| CdsA | PssA | PTH_1258 | PTH_1986 | CDP-diglyceride synthetase; Belongs to the CDS family. | Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.928 |
| CysE | GlyA | PTH_0294 | PTH_2824 | Serine acetyltransferase. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.857 |
| CysE | GpmB-2 | PTH_0294 | PTH_1315 | Serine acetyltransferase. | Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. | 0.807 |
| CysE | IlvA | PTH_0294 | PTH_0102 | Serine acetyltransferase. | Threonine dehydratase. | 0.833 |
| CysE | PssA | PTH_0294 | PTH_1986 | Serine acetyltransferase. | Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.803 |
| CysE | TrpA | PTH_0294 | PTH_1623 | Serine acetyltransferase. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.814 |
| CysE | TrpB | PTH_0294 | PTH_1624 | Serine acetyltransferase. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.813 |
| CysE | trpB | PTH_0294 | PTH_0608 | Serine acetyltransferase. | Predicted alternative tryptophan synthase beta-subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.800 |
| GlyA | CysE | PTH_2824 | PTH_0294 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine acetyltransferase. | 0.857 |
| GlyA | GpmB-2 | PTH_2824 | PTH_1315 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. | 0.914 |
| GlyA | IlvA | PTH_2824 | PTH_0102 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase. | 0.941 |
| GlyA | PssA | PTH_2824 | PTH_1986 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| GlyA | TrpA | PTH_2824 | PTH_1623 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.946 |
| GlyA | TrpB | PTH_2824 | PTH_1624 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.922 |
| GlyA | trpB | PTH_2824 | PTH_0608 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Predicted alternative tryptophan synthase beta-subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.907 |
| GpmB-2 | CysE | PTH_1315 | PTH_0294 | Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. | Serine acetyltransferase. | 0.807 |
| GpmB-2 | GlyA | PTH_1315 | PTH_2824 | Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.914 |
| GpmB-2 | IlvA | PTH_1315 | PTH_0102 | Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. | Threonine dehydratase. | 0.918 |
| GpmB-2 | PssA | PTH_1315 | PTH_1986 | Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. | Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |