STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RsbUSerine phosphatase RsbU; Regulator of sigma subunit. (452 aa)    
Predicted Functional Partners:
RsbW-2
Anti-sigma regulatory factor; Ser/Thr protein kinase.
 
 0.997
SpoIIAA-2
Anti-anti-sigma regulatory factor; Antagonist of anti-sigma factor; Belongs to the anti-sigma-factor antagonist family.
 
 
 0.978
PTH_2276
Hypothetical protein; Containing SpoIIAA (COG1366), anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); Belongs to the anti-sigma-factor antagonist family.
 
 
 0.964
PTH_0142
Hypothetical protein; Containing predicted ATPase (COG3899), FhlA, FOG: GAF domain (COG2203), S_TKc, serine/threonine protein kinases, catalytic domain, His Kinase A (phosphoacceptor), HATPase_c, Histidine kinase-like ATPase, REC, signal receiver domain, and ArcB, FOG: HPt domain (COG2198).
 
  
 0.947
PTH_0654
Hypothetical regulator protein; Containing LytS (COG3275), putative regulator of cell autolysis.
 
     0.937
BaeS-4
Signal transduction histidine kinase.
  
 0.899
RsbW
Anti-sigma regulatory factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
 
 0.776
FliM
Flagellar motor switch protein.
  
    0.708
FliG
Flagellar motor switch protein.
  
    0.707
PTH_1663
Hypothetical protein; Containing COG2202, AtoS, FOG: PAS/PAC domain, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain, and HDc, Metal dependent phosphohydrolases with conserved 'HD' motif.
  
  
 0.700
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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