STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTH_2276Hypothetical protein; Containing SpoIIAA (COG1366), anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); Belongs to the anti-sigma-factor antagonist family. (436 aa)    
Predicted Functional Partners:
RsbW-2
Anti-sigma regulatory factor; Ser/Thr protein kinase.
 
 
 0.979
RsbU
Serine phosphatase RsbU; Regulator of sigma subunit.
 
 
 0.941
RsbW
Anti-sigma regulatory factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
 
 0.912
PTH_0142
Hypothetical protein; Containing predicted ATPase (COG3899), FhlA, FOG: GAF domain (COG2203), S_TKc, serine/threonine protein kinases, catalytic domain, His Kinase A (phosphoacceptor), HATPase_c, Histidine kinase-like ATPase, REC, signal receiver domain, and ArcB, FOG: HPt domain (COG2198).
  
  
 0.894
FliY
Flagellum motor switch protein.
  
   0.868
BaeS-4
Signal transduction histidine kinase.
  
  
 0.853
FlgB
Flagellar basal body protein; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
   
    0.731
FliG
Flagellar motor switch protein.
  
   0.692
FliF
Flagellar biosynthesis/type III secretory pathway lipoprotein; The M ring may be actively involved in energy transduction. Belongs to the FliF family.
  
    0.636
FliL
Flagellar basal body-associated protein; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family.
  
    0.620
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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