Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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PTH_2407Hypothetical membrane protein; Containing GloB (COG0491), Zn-dependent hydrolases, including glyoxylases and partial LytE (COG1388), FOG: LysM repeat. (396 aa)    
Predicted Functional Partners:
HcaD
Uncharacterized NAD(FAD)-dependent dehydrogenases and rhodanese-related sulfurtransferase.
  
 0.677
PTH_1734
Uncharacterized NAD(FAD)-dependent dehydrogenases; Containing PspE, rhodanese-related sulfurtransferase (COG0607).
  
 0.677
PTH_0142
Hypothetical protein; Containing predicted ATPase (COG3899), FhlA, FOG: GAF domain (COG2203), S_TKc, serine/threonine protein kinases, catalytic domain, His Kinase A (phosphoacceptor), HATPase_c, Histidine kinase-like ATPase, REC, signal receiver domain, and ArcB, FOG: HPt domain (COG2198).
 
 
 0.673
Tdh-3
Threonine dehydrogenase and related Zn-dependent dehydrogenases.
 
 
 
 0.561
FtsI-4
Cell division protein FtsI/penicillin-binding protein 2; With 2x PASTA domain.
  
 
 0.530
guaA
Hypothetical GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.477
PTH_1236
Hypothetical protein; Containing COG0517and COG0617 domains; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
  
 0.421
SerA
Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
     
 0.409
nnrE
Predicted Carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...]
  
  
 0.402
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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