STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ThiS-3Sulfur transfer protein; Involved in thiamine biosynthesis. (76 aa)    
Predicted Functional Partners:
PTH_0642
Predicted dinucleotide-utilizing enzyme; ThiF/HesA family.
  
 0.969
ThiG
Uncharacterized enzyme; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.945
ThiS-2
Sulfur transfer protein; Involved in thiamine biosynthesis.
     
  0.900
ThiE
Thiamine monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.727
ThiC
Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.717
ThiF
Dinucleotide-utilizing enzymes; Involved in molybdopterin and thiamine biosynthesis family 2.
  
 
 0.708
ThiF-2
Dinucleotide-utilizing enzymes; Involved in molybdopterin and thiamine biosynthesis family 2.
  
 
 0.708
ThiF-3
Dinucleotide-utilizing enzymes; Involved in molybdopterin and thiamine biosynthesis family 2.
  
 
 0.708
ThiF-4
Dinucleotide-utilizing enzymes; Involved in molybdopterin and thiamine biosynthesis family 2.
  
 
 0.708
ThiD
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
  
    0.682
Your Current Organism:
Pelotomaculum thermopropionicum
NCBI taxonomy Id: 370438
Other names: P. thermopropionicum SI, Pelotomaculum thermopropionicum SI, Pelotomaculum thermopropionicum str. SI, Pelotomaculum thermopropionicum strain SI
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