node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDG94678.1 | SDH20294.1 | SAMN04489810_1725 | SAMN04489810_2372 | NTP pyrophosphatase, house-cleaning of non-canonical NTPs. | Nucleoside diphosphate kinase. | 0.701 |
SDG94678.1 | dcd | SAMN04489810_1725 | SAMN04489810_0569 | NTP pyrophosphatase, house-cleaning of non-canonical NTPs. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.692 |
SDG99230.1 | SDG99327.1 | SAMN04489810_1838 | SAMN04489810_1840 | Ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit. | Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.997 |
SDG99230.1 | dcd | SAMN04489810_1838 | SAMN04489810_0569 | Ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.510 |
SDG99327.1 | SDG99230.1 | SAMN04489810_1840 | SAMN04489810_1838 | Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit. | 0.997 |
SDG99327.1 | SDH20294.1 | SAMN04489810_1840 | SAMN04489810_2372 | Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Nucleoside diphosphate kinase. | 0.937 |
SDG99327.1 | dcd | SAMN04489810_1840 | SAMN04489810_0569 | Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.511 |
SDG99327.1 | dut | SAMN04489810_1840 | SAMN04489810_2533 | Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.860 |
SDG99327.1 | pyrG | SAMN04489810_1840 | SAMN04489810_2853 | Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.510 |
SDG99327.1 | thyA | SAMN04489810_1840 | SAMN04489810_2922 | Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.826 |
SDG99327.1 | tmk | SAMN04489810_1840 | SAMN04489810_1613 | Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.905 |
SDH03340.1 | dcd | SAMN04489810_1941 | SAMN04489810_0569 | XTP/dITP diphosphohydrolase. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.771 |
SDH03340.1 | dut | SAMN04489810_1941 | SAMN04489810_2533 | XTP/dITP diphosphohydrolase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.433 |
SDH03340.1 | pyrG | SAMN04489810_1941 | SAMN04489810_2853 | XTP/dITP diphosphohydrolase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.792 |
SDH20294.1 | SDG94678.1 | SAMN04489810_2372 | SAMN04489810_1725 | Nucleoside diphosphate kinase. | NTP pyrophosphatase, house-cleaning of non-canonical NTPs. | 0.701 |
SDH20294.1 | SDG99327.1 | SAMN04489810_2372 | SAMN04489810_1840 | Nucleoside diphosphate kinase. | Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.937 |
SDH20294.1 | dcd | SAMN04489810_2372 | SAMN04489810_0569 | Nucleoside diphosphate kinase. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.889 |
SDH20294.1 | dut | SAMN04489810_2372 | SAMN04489810_2533 | Nucleoside diphosphate kinase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.959 |
SDH20294.1 | pyrG | SAMN04489810_2372 | SAMN04489810_2853 | Nucleoside diphosphate kinase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.953 |
SDH20294.1 | tmk | SAMN04489810_2372 | SAMN04489810_1613 | Nucleoside diphosphate kinase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.946 |