STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDH29143.1Dihydrofolate reductase. (195 aa)    
Predicted Functional Partners:
SDH29162.1
Glyoxylase, beta-lactamase superfamily II.
       0.773
SDH29120.1
DNA-binding transcriptional regulator, HxlR family.
 
     0.608
SDH00205.1
Dihydrofolate reductase.
  
     0.599
SDH29049.1
Dihydrofolate reductase.
 
     0.589
SDH29098.1
Hypothetical protein.
       0.552
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.540
SDG39388.1
Dihydrofolate reductase.
  
     0.518
SDG91755.1
Dihydrofolate reductase.
  
     0.439
SDH29076.1
Sugar phosphate permease.
       0.439
Your Current Organism:
Microbacterium pygmaeum
NCBI taxonomy Id: 370764
Other names: DSM 23142, JCM 15925, M. pygmaeum, Microbacterium pygmaeum Kageyama et al. 2008, Microbacterium sp. KV-490, NBRC 101800, NRRL B-24469, strain KV-490
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