node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHG01052.1 | guaA | SAMN05443663_101783 | SAMN05443663_1065 | Amidophosphoribosyltransferase. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.813 |
SHG01052.1 | queE | SAMN05443663_101783 | SAMN05443663_103559 | Amidophosphoribosyltransferase. | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.527 |
SHG67737.1 | SHG91384.1 | SAMN05443663_103445 | SAMN05443663_104263 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | 0.912 |
SHG67737.1 | folE | SAMN05443663_103445 | SAMN05443663_10689 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | GTP cyclohydrolase I. | 0.926 |
SHG67737.1 | queE | SAMN05443663_103445 | SAMN05443663_103559 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.984 |
SHG69704.1 | queE | SAMN05443663_103490 | SAMN05443663_103559 | Acyl-protein synthetase, LuxE. | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.577 |
SHG72862.1 | queE | SAMN05443663_103558 | SAMN05443663_103559 | Tetratricopeptide repeat-containing protein. | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.526 |
SHG91384.1 | SHG67737.1 | SAMN05443663_104263 | SAMN05443663_103445 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | 0.912 |
SHG91384.1 | folE | SAMN05443663_104263 | SAMN05443663_10689 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | GTP cyclohydrolase I. | 0.929 |
SHG91384.1 | queE | SAMN05443663_104263 | SAMN05443663_103559 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.979 |
SHG91384.1 | tgt | SAMN05443663_104263 | SAMN05443663_10418 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.420 |
dut | queE | SAMN05443663_10351 | SAMN05443663_103559 | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.577 |
folE | SHG67737.1 | SAMN05443663_10689 | SAMN05443663_103445 | GTP cyclohydrolase I. | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | 0.926 |
folE | SHG91384.1 | SAMN05443663_10689 | SAMN05443663_104263 | GTP cyclohydrolase I. | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | 0.929 |
folE | queE | SAMN05443663_10689 | SAMN05443663_103559 | GTP cyclohydrolase I. | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.617 |
guaA | SHG01052.1 | SAMN05443663_1065 | SAMN05443663_101783 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Amidophosphoribosyltransferase. | 0.813 |
guaA | queE | SAMN05443663_1065 | SAMN05443663_103559 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.516 |
guaA | tgt | SAMN05443663_1065 | SAMN05443663_10418 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.665 |
queA | queE | SAMN05443663_103538 | SAMN05443663_103559 | S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.535 |
queA | tgt | SAMN05443663_103538 | SAMN05443663_10418 | S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.994 |