node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KGT91758.1 | lapA | NG99_15420 | NG99_20835 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Membrane protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. | 0.615 |
KGT91758.1 | lapB | NG99_15420 | NG99_20830 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. | 0.927 |
KGT94468.1 | KGT94641.1 | NG99_07510 | NG99_08505 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.669 |
KGT94468.1 | ftsN | NG99_07510 | NG99_03885 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.758 |
KGT94468.1 | lapB | NG99_07510 | NG99_20830 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. | 0.684 |
KGT94468.1 | lpxH | NG99_07510 | NG99_23540 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.409 |
KGT94468.1 | lpxM | NG99_07510 | NG99_25250 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. | 0.686 |
KGT94468.1 | zapB | NG99_07510 | NG99_03860 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Septal ring assembly protein ZapB; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.781 |
KGT94641.1 | KGT94468.1 | NG99_08505 | NG99_07510 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.669 |
KGT94641.1 | ftsN | NG99_08505 | NG99_03885 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.746 |
KGT94641.1 | lapB | NG99_08505 | NG99_20830 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. | 0.744 |
KGT94641.1 | lpxH | NG99_08505 | NG99_23540 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.620 |
KGT94641.1 | lpxM | NG99_08505 | NG99_25250 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. | 0.735 |
KGT94641.1 | zapB | NG99_08505 | NG99_03860 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Septal ring assembly protein ZapB; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.686 |
ftsB | ftsN | NG99_11860 | NG99_03885 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.404 |
ftsB | lapB | NG99_11860 | NG99_20830 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Tetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. | 0.682 |
ftsB | lpxH | NG99_11860 | NG99_23540 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.553 |
ftsN | KGT94468.1 | NG99_03885 | NG99_07510 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.758 |
ftsN | KGT94641.1 | NG99_03885 | NG99_08505 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.746 |
ftsN | ftsB | NG99_03885 | NG99_11860 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.404 |