Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)    
Predicted Functional Partners:
H2AC6
Histone H2A; Belongs to the histone H2A family.
   
  0.994
H2AJ
Histone H2A; Belongs to the histone H2A family.
   
  0.994
H2AC7
Histone H2A; Belongs to the histone H2A family.
   
 0.994
H2AC21
Histone H2A; Belongs to the histone H2A family.
   
  0.990
H2BC18
Histone H2B; Belongs to the histone H2B family.
  
 0.977
RNF168
E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]
    
 0.964
LOC105726422
Histone H2B; Belongs to the histone H2B family.
  
 0.962
LOC105721506
Histone H2B; Belongs to the histone H2B family.
  
 0.957
EP300
E1A binding protein p300.
    
 0.950
LOC110568754
Histone H3; Belongs to the histone H3 family.
   
 0.948
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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