STAM2 protein (Aotus nancymaae) - STRING interaction network

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Score

STAM2

Signal transducing adaptor molecule 2. (525 aa)

Predicted Functional Partners:

HGS

0.999

STAM

0.997

USP8

0.990

STAMBP

0.979

JAK1

0.973

JAK3

0.959

TYK2

0.955

JAK2

0.947

TSG101

0.943

PTPN23

0.936

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HGS	PTPN23	ENSANAP00000006705	ENSANAP00000024448	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Uncharacterized protein.	0.879
HGS	STAM	ENSANAP00000006705	ENSANAP00000019442	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adaptor molecule.	0.999
HGS	STAM2	ENSANAP00000006705	ENSANAP00000000097	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adaptor molecule 2.	0.999
HGS	TSG101	ENSANAP00000006705	ENSANAP00000003603	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Tumor susceptibility 101.	0.998
HGS	USP8	ENSANAP00000006705	ENSANAP00000041236	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family.	0.972
JAK1	JAK2	ENSANAP00000038503	ENSANAP00000018379	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.997
JAK1	JAK3	ENSANAP00000038503	ENSANAP00000001288	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.997
JAK1	STAM	ENSANAP00000038503	ENSANAP00000019442	Tyrosine-protein kinase.	Signal transducing adaptor molecule.	0.923
JAK1	STAM2	ENSANAP00000038503	ENSANAP00000000097	Tyrosine-protein kinase.	Signal transducing adaptor molecule 2.	0.973
JAK1	TYK2	ENSANAP00000038503	ENSANAP00000038810	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.975
JAK2	JAK1	ENSANAP00000018379	ENSANAP00000038503	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.997
JAK2	JAK3	ENSANAP00000018379	ENSANAP00000001288	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.962
JAK2	STAM	ENSANAP00000018379	ENSANAP00000019442	Tyrosine-protein kinase.	Signal transducing adaptor molecule.	0.962
JAK2	STAM2	ENSANAP00000018379	ENSANAP00000000097	Tyrosine-protein kinase.	Signal transducing adaptor molecule 2.	0.947
JAK2	TYK2	ENSANAP00000018379	ENSANAP00000038810	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.984
JAK3	JAK1	ENSANAP00000001288	ENSANAP00000038503	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.997
JAK3	JAK2	ENSANAP00000001288	ENSANAP00000018379	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.962
JAK3	STAM	ENSANAP00000001288	ENSANAP00000019442	Tyrosine-protein kinase.	Signal transducing adaptor molecule.	0.954
JAK3	STAM2	ENSANAP00000001288	ENSANAP00000000097	Tyrosine-protein kinase.	Signal transducing adaptor molecule 2.	0.959
JAK3	TYK2	ENSANAP00000001288	ENSANAP00000038810	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.956