EEA1 protein (Aotus nancymaae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

EEA1

Early endosome antigen 1. (1411 aa)

Predicted Functional Partners:

RAB5C

0.974

RAB5A

0.950

RAB5B

0.950

PIK3C3

0.943

RABEP1

0.854

ERBB2

0.841

HGS

0.835

STAM

0.829

ENSANAP00000041290

0.828

SNX27

0.805

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEA1	ENSANAP00000041290	ENSANAP00000001005	ENSANAP00000041290	Early endosome antigen 1.	Uncharacterized protein.	0.828
EEA1	ERBB2	ENSANAP00000001005	ENSANAP00000014406	Early endosome antigen 1.	Receptor protein-tyrosine kinase.	0.841
EEA1	HGS	ENSANAP00000001005	ENSANAP00000006705	Early endosome antigen 1.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.835
EEA1	PIK3C3	ENSANAP00000001005	ENSANAP00000036407	Early endosome antigen 1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.943
EEA1	RAB5A	ENSANAP00000001005	ENSANAP00000014435	Early endosome antigen 1.	Uncharacterized protein.	0.950
EEA1	RAB5B	ENSANAP00000001005	ENSANAP00000030988	Early endosome antigen 1.	RAB5B, member RAS oncogene family.	0.950
EEA1	RAB5C	ENSANAP00000001005	ENSANAP00000015018	Early endosome antigen 1.	RAB5C, member RAS oncogene family.	0.974
EEA1	RABEP1	ENSANAP00000001005	ENSANAP00000020926	Early endosome antigen 1.	Rabaptin, RAB GTPase binding effector protein 1.	0.854
EEA1	SNX27	ENSANAP00000001005	ENSANAP00000033383	Early endosome antigen 1.	Sorting nexin 27.	0.805
EEA1	STAM	ENSANAP00000001005	ENSANAP00000019442	Early endosome antigen 1.	Signal transducing adaptor molecule.	0.829
ENSANAP00000041290	EEA1	ENSANAP00000041290	ENSANAP00000001005	Uncharacterized protein.	Early endosome antigen 1.	0.828
ENSANAP00000041290	HGS	ENSANAP00000041290	ENSANAP00000006705	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.593
ENSANAP00000041290	PIK3C3	ENSANAP00000041290	ENSANAP00000036407	Uncharacterized protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.755
ENSANAP00000041290	RAB5B	ENSANAP00000041290	ENSANAP00000030988	Uncharacterized protein.	RAB5B, member RAS oncogene family.	0.462
ENSANAP00000041290	RABEP1	ENSANAP00000041290	ENSANAP00000020926	Uncharacterized protein.	Rabaptin, RAB GTPase binding effector protein 1.	0.833
ENSANAP00000041290	STAM	ENSANAP00000041290	ENSANAP00000019442	Uncharacterized protein.	Signal transducing adaptor molecule.	0.517
ERBB2	EEA1	ENSANAP00000014406	ENSANAP00000001005	Receptor protein-tyrosine kinase.	Early endosome antigen 1.	0.841
ERBB2	HGS	ENSANAP00000014406	ENSANAP00000006705	Receptor protein-tyrosine kinase.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.836
ERBB2	STAM	ENSANAP00000014406	ENSANAP00000019442	Receptor protein-tyrosine kinase.	Signal transducing adaptor molecule.	0.583
HGS	EEA1	ENSANAP00000006705	ENSANAP00000001005	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Early endosome antigen 1.	0.835