Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC110568754Histone H3; Belongs to the histone H3 family. (136 aa)    
Predicted Functional Partners:
CBX5
Chromobox 5.
    
 0.968
WDR5
WD repeat domain 5.
   
 0.967
EP300
E1A binding protein p300.
    
 0.963
KMT2A
Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
    
 0.958
EZH2
Enhancer of zeste 2 polycomb repressive complex 2 subunit.
    
 0.953
HAT1
Histone acetyltransferase 1.
    
 0.949
H2AC20
Histone H2A; Belongs to the histone H2A family.
   
 0.948
AURKB
Aurora kinase B; Belongs to the protein kinase superfamily.
   
 
 0.947
SETDB1
SET domain bifurcated histone lysine methyltransferase 1.
    
 0.939
LOC105713881
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.939
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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