PAX2 protein (Aotus nancymaae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PAX2

Paired box 2. (416 aa)

Predicted Functional Partners:

ETS1

0.881

GSC

0.799

ETS2

0.772

PAXIP1

0.563

RUNX1

0.556

RUNX2

0.556

CBFB

0.551

RUNX3

0.541

PTF1A

0.538

EYA1

0.538

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBFB	ETS1	ENSANAP00000002909	ENSANAP00000012749	Core-binding factor subunit beta.	ETS proto-oncogene 1, transcription factor.	0.775
CBFB	ETS2	ENSANAP00000002909	ENSANAP00000035452	Core-binding factor subunit beta.	ETS proto-oncogene 2, transcription factor.	0.553
CBFB	PAX2	ENSANAP00000002909	ENSANAP00000001115	Core-binding factor subunit beta.	Paired box 2.	0.551
CBFB	RUNX1	ENSANAP00000002909	ENSANAP00000024288	Core-binding factor subunit beta.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.983
CBFB	RUNX2	ENSANAP00000002909	ENSANAP00000033258	Core-binding factor subunit beta.	RUNX family transcription factor 2.	0.976
CBFB	RUNX3	ENSANAP00000002909	ENSANAP00000024592	Core-binding factor subunit beta.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.965
ETS1	CBFB	ENSANAP00000012749	ENSANAP00000002909	ETS proto-oncogene 1, transcription factor.	Core-binding factor subunit beta.	0.775
ETS1	ETS2	ENSANAP00000012749	ENSANAP00000035452	ETS proto-oncogene 1, transcription factor.	ETS proto-oncogene 2, transcription factor.	0.920
ETS1	PAX2	ENSANAP00000012749	ENSANAP00000001115	ETS proto-oncogene 1, transcription factor.	Paired box 2.	0.881
ETS1	RUNX1	ENSANAP00000012749	ENSANAP00000024288	ETS proto-oncogene 1, transcription factor.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.937
ETS1	RUNX2	ENSANAP00000012749	ENSANAP00000033258	ETS proto-oncogene 1, transcription factor.	RUNX family transcription factor 2.	0.897
ETS1	RUNX3	ENSANAP00000012749	ENSANAP00000024592	ETS proto-oncogene 1, transcription factor.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.876
ETS2	CBFB	ENSANAP00000035452	ENSANAP00000002909	ETS proto-oncogene 2, transcription factor.	Core-binding factor subunit beta.	0.553
ETS2	ETS1	ENSANAP00000035452	ENSANAP00000012749	ETS proto-oncogene 2, transcription factor.	ETS proto-oncogene 1, transcription factor.	0.920
ETS2	PAX2	ENSANAP00000035452	ENSANAP00000001115	ETS proto-oncogene 2, transcription factor.	Paired box 2.	0.772
ETS2	RUNX1	ENSANAP00000035452	ENSANAP00000024288	ETS proto-oncogene 2, transcription factor.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.802
ETS2	RUNX2	ENSANAP00000035452	ENSANAP00000033258	ETS proto-oncogene 2, transcription factor.	RUNX family transcription factor 2.	0.780
ETS2	RUNX3	ENSANAP00000035452	ENSANAP00000024592	ETS proto-oncogene 2, transcription factor.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.780
EYA1	PAX2	ENSANAP00000019169	ENSANAP00000001115	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Paired box 2.	0.538
GSC	PAX2	ENSANAP00000026844	ENSANAP00000001115	Goosecoid homeobox.	Paired box 2.	0.799