Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
JAK3Tyrosine-protein kinase. (1119 aa)    
Predicted Functional Partners:
IL2RG
Fibronectin type-III domain-containing protein.
   
 0.999
JAK1
Tyrosine-protein kinase.
   
0.997
IL2RB
Interleukin 2 receptor subunit beta.
   
 0.995
STAT3
Signal transducer and activator of transcription.
   
 0.995
SOCS3
Suppressor of cytokine signaling 3.
   
 0.993
STAT6
Signal transducer and activator of transcription.
    
 0.993
SOCS1
Suppressor of cytokine signaling 1.
    
 0.993
IFNGR2
Interferon gamma receptor 2.
    
 0.991
PTPN11
Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.
    
 0.990
STAT5B
Signal transducer and activator of transcription.
    
 0.990
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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